• 1
    Meldrum BS (2000) Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130, 1007S1015S.
  • 2
    Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T & Lipton SA (2013) S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci USA 110, 31373142.
  • 3
    Brennan-Minnella AM, Shen Y & Swanson RA (2013) Phosphoinositide 3-kinase couples NMDA receptors to superoxide release in excitotoxic neuronal death. Cell Death Dis 4, e580, 1–10.
  • 4
    Brittain JM, Chen L, Wilson SM, Brustovetsky T, Gao X, Ashpole NM, Molosh AI, You H, Hudmon A, Shekhar A et al. (2011) Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2). J Biol Chem 286, 3777837792.
  • 5
    Bell JD, Park E, Ai J & Baker AJ (2009) PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma. Cell Death Differ 16, 16651680.
  • 6
    Degos V, Peineau S, Nijboer C, Kaindl AM, Sigaut S, Favrais G, Plaisant F, Teissier N, Gouadon E, Lombet A et al. (2013) G protein-coupled receptor kinase 2 and group I metabotropic glutamate receptors mediate inflammation-induced sensitization to excitotoxic neurodegeneration. Ann Neurol 78, 667678.
  • 7
    Ong WY, Tanaka K, Dawe GS, Ittner LM & Farooqui AA (2013) Slow excitotoxicity in Alzheimer's disease. J Alzheimers Dis 35, 643668.
  • 8
    Hsieh MH, Ho SC, Yeh KY, Pawlak CR, Chang HM, Ho YJ, Lai TJ & Wu FY (2012) Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model. Pharmacol Biochem Behav 102, 6471.
  • 9
    Morales I, Sabate M & Rodriguez M (2013) Striatal glutamate induces retrograde excitotoxicity and neuronal degeneration of intralaminar thalamic nuclei: their potential relevance for Parkinson's disease. Eur J Neurosci 38, 21722182.
  • 10
    Bell KF, Bent RJ, Meese-Tamuri S, Ali A, Forder JP & Aarts MM (2013) Calmodulin kinase IV-dependent CREB activation is required for neuroprotection via NMDA receptor-PSD95 disruption. J Neurochem 126, 274287.
  • 11
    Martel MA, Ryan TJ, Bell KF, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SG et al. (2012) The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron 74, 543556.
  • 12
    Chen T, Fei F, Jiang XF, Zhang L, Qu Y, Huo K & Fei Z (2012) Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons. Free Radic Biol Med 52, 208217.
  • 13
    Zhou L, Li F, Xu HB, Luo CX, Wu HY, Zhu MM, Lu W, Ji X, Zhou QG & Zhu DY (2010) Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 16, 14391443.
  • 14
    Bach A, Clausen BH, Moller M, Vestergaard B, Chi CN, Round A, Sorensen PL, Nissen KB, Kastrup JS, Gajhede M et al. (2012) A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci USA 109, 33173322.
  • 15
    Hu JH, Park JM, Park S, Xiao B, Dehoff MH, Kim S, Hayashi T, Schwarz MK, Huganir RL, Seeburg PH et al. (2010) Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron 68, 11281142.
  • 16
    Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG, Hu JH, Worley PF, Gibson JR & Huber KM (2012) Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nat Neurosci 15, 431440, S1.
  • 17
    Lee HW, Choi J, Shin H, Kim K, Yang J, Na M, Choi SY, Kang GB, Eom SH, Kim H et al. (2008) Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. J Neurosci 28, 1454614556.
  • 18
    Mo J, Lee D, Hong S, Han S, Yeo H, Sun W, Choi S, Kim H & Lee HW (2012) Preso regulation of dendritic outgrowth through PI(4,5)P2-dependent PDZ interaction with betaPix. Eur J Neurosci 36, 19601970.
  • 19
    Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW et al. (2012) Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci 15, 836844.
  • 20
    Sheng M & Hoogenraad CC (2007) The postsynaptic architecture of excitatory synapses: a more quantitative view. Annu Rev Biochem 76, 823847.
  • 21
    Fan J, Vasuta OC, Zhang LY, Wang L, George A & Raymond LA (2010) N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95. J Neurochem 115, 10451056.
  • 22
    Hara MR & Snyder SH (2007) Cell signaling and neuronal death. Annu Rev Pharmacol Toxicol 47, 117141.
  • 23
    Luo P, Chen T, Zhao Y, Xu H, Huo K, Zhao M, Yang Y & Fei Z (2012) Protective effect of Homer 1a against hydrogen peroxide-induced oxidative stress in PC12 cells. Free Radic Res 46, 766776.
  • 24
    Zhou X, Ding Q, Chen Z, Yun H & Wang H (2013) Involvement of GluN2A and GluN2B in synaptic and extrasynaptic NMDA receptor function and neuronal excitotoxicity. J Biol Chem 288, 2415124159.
  • 25
    Castillo CA, Leon DA, Ballesteros-Yanez I, Iglesias I, Martin M & Albasanz JL (2010) Glutamate differently modulates metabotropic glutamate receptors in neuronal and glial cells. Neurochem Res 35, 10501063.
  • 26
    Lau A & Tymianski M (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460, 525542.
  • 27
    Luo P, Fei F, Zhang L, Qu Y & Fei Z (2011) The role of glutamate receptors in traumatic brain injury: implications for postsynaptic density in pathophysiology. Brain Res Bull 85, 313320.
  • 28
    Cook DJ, Teves L & Tymianski M (2012) Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature 483, 213217.
  • 29
    Paoletti P, Bellone C & Zhou Q (2013) NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci 14, 383400.
  • 30
    Niswender CM & Conn PJ (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 50, 295322.
  • 31
    Stanika RI, Pivovarova NB, Brantner CA, Watts CA, Winters CA & Andrews SB (2009) Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci USA 106, 98549859.
  • 32
    Hilton GD, Nunez JL, Bambrick L, Thompson SM & McCarthy MM (2006) Glutamate-mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR-induced release of Ca++ from intracellular stores and is prevented by estradiol. Eur J Neurosci 24, 30083016.
  • 33
    Padanyi R, Paszty K, Strehler EE & Enyedi A (2009) PSD-95 mediates membrane clustering of the human plasma membrane Ca2+ pump isoform 4b. Biochim Biophys Acta 1793, 10231032.
  • 34
    Huang G, Kim JY, Dehoff M, Mizuno Y, Kamm KE, Worley PF, Muallem S & Zeng W (2007) Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation–contraction coupling. J Biol Chem 282, 1428314290.
  • 35
    Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T & Sugimoto H (2010) Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors. Br J Pharmacol 161, 127139.