J. H. van Wonderen, R. M. McMahon and M. L. O'Mara contributed equally to this work.
The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis
Version of Record online: 1 APR 2014
© 2014 FEBS
The FEBS Journal
Volume 281, Issue 9, pages 2190–2201, May 2014
How to Cite
van Wonderen, J. H., McMahon, R. M., O'Mara, M. L., McDevitt, C. A., Thomson, A. J., Kerr, I. D., MacMillan, F. and Callaghan, R. (2014), The central cavity of ABCB1 undergoes alternating access during ATP hydrolysis. The FEBS Journal, 281: 2190–2201. doi: 10.1111/febs.12773
- Issue online: 1 MAY 2014
- Version of Record online: 1 APR 2014
- Accepted manuscript online: 6 MAR 2014 02:24AM EST
- Manuscript Accepted: 28 FEB 2014
- Manuscript Revised: 18 FEB 2014
- Manuscript Received: 17 JAN 2014
- Wellcome Trust Project Grant. Grant Number: 094392/B/10/Z
- Royal Society Wolfson Research merit Award
Fig. S1. The Cα rmsd of the ABCB1 TMDs after labelling introduced cysteine residues with MTSL.
Fig. S2. Accessibility of MTSL-labelled residues to quenching agents.
Fig. S3. EPR accessibility measurements.
Fig. S4. Orientation of the MTSL moiety in ABCB1 mutant isoforms.
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