Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme 4 is required for chondrogenic differentiation in ATDC5 cells (pages 3997–4009)
Keizo Yuasa, Go Futamatsu, Tsuyoshi Kawano, Masaki Muroshita, Yoko Kageyama, Hiromi Taichi, Hiroshi Ishikawa, Masami Nagahama, Yoshiko Matsuda and Akihiko Tsuji
Version of Record online: 17 SEP 2012 | DOI: 10.1111/j.1742-4658.2012.08758.x
Bone morphogenetic proteins (BMPs) are implicated in the regulation of multiple stages of endochondral bone development. The SPC family proteolytically activates various signaling molecules including BMPs. PACE4 mRNA levels increased markedly during chondrogenic differentiation in ATDC5 cells, whereas the furin expression remained unchanged. Knockdown of PACE4 expression reduced chondrogenic differentiation. These results indicate that PACE4 is required for chondrogenic differentiation in ATDC5 cells.