A role for p21-activated kinase 7 in the development of gastric cancer (pages 46–55)
Jun Gu, Keqiang Li, Maolan Li, Xiangsong Wu, Lin Zhang, Qichen Ding, Wenguang Wu, Jiahua Yang, Jiasheng Mu, Hao Wen, Qian Ding, Jianhua Lu, Yuan Hao, Lei Chen, Wenjie Zhang, Songgang Li and Yingbin Liu
Article first published online: 23 NOV 2012 | DOI: 10.1111/febs.12048
p21-activated kinase (PAK)7 was related to gastric cancer progression. Knockdown of PAK7 inhibited human gastric cancer cell proliferation by inducing cell cycle arrest in the G0/G1 phase in concordance with the down-regulation of CDK2, CDC25A and cyclin D1. Our data suggest that PAK7 is a new hallmark and may be a candidate for the therapeutic target of gastric cancer.