Initiation of the transcriptional response to hyperosmotic shock correlates with the potential for volume recovery (pages 3854–3867)
Cecilia Geijer, Dagmara Medrala-Klein, Elzbieta Petelenz-Kurdziel, Abraham Ericsson, Maria Smedh, Mikael Andersson, Mattias Goksör, Mariona Nadal-Ribelles, Francesc Posas, Marcus Krantz, Bodil Nordlander and Stefan Hohmann
Article first published online: 5 JUL 2013 | DOI: 10.1111/febs.12382
Signal transduction components such as MAP kinases shuttle into the nucleus to activate transcription. It is not known how different amounts of nuclear MAPK over time affect the transcriptional response. We found that the initial transcriptional response correlates with the potential of cells for rapid adaptation and that the period of Hog1 nuclear residence affects the amplitude of the transcriptional response rather than the spectrum of responsive genes.