Pathogens and Disease

Cover image for Vol. 68 Issue 2

July 2013

Volume 68, Issue 2

Pages i–ii, 39–64

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Shortomics
    4. Host Responses to Infection
    1. Issue Information (pages i–ii)

      Version of Record online: 21 JUN 2013 | DOI: 10.1111/j.1574-695X.2013.01019.x

  2. Shortomics

    1. Top of page
    2. Issue Information
    3. Shortomics
    4. Host Responses to Infection
    1. Short Communication

      Genome sequences of 65 Helicobacter pylori strains isolated from asymptomatic individuals and patients with gastric cancer, peptic ulcer disease, or gastritis (pages 39–43)

      Thomas G. Blanchard, Steven J. Czinn, Pelayo Correa, Teruko Nakazawa, Monika Keelan, Lindsay Morningstar, Ivette Santana-Cruz, Ankit Maroo, Carri McCracken, Kent Shefchek, Sean Daugherty, Yang Song, Claire M. Fraser and W. Florian Fricke

      Version of Record online: 23 MAY 2013 | DOI: 10.1111/2049-632X.12045

      This study provides a great resource for the Helicobacter pylori research community. It is the largest genome sequencing effort in this species so far and it provides an unprecedented overview of genomic diversity within the species. Both the raw data and assembled scaffolds are made available.

  3. Host Responses to Infection

    1. Top of page
    2. Issue Information
    3. Shortomics
    4. Host Responses to Infection
    1. Research Articles

      The responses of γδ T-cells against acute Pseudomonas aeruginosa pulmonary infection in mice via interleukin-17 (pages 44–51)

      Jialin Liu, Hongping Qu, Qingyun Li, Liang Ye, Guanhua Ma and Huanying Wan

      Version of Record online: 15 MAY 2013 | DOI: 10.1111/2049-632X.12043

      This paper seems to demonstrate that IL17 plays an important role in protection in early stage Pseudomonas aeruginosa-induced disease. By depleting either IL17 or gamma delta T cells, the authors show that the effects of the cytokine and T cell subset are fully overlapping, which provides a strong argument for their conclusion, i.e. that gamma delta T cells are the source of IL17 early in infection. This is potentially a new and exciting role of gamma delta T cells in infection.

    2. Hepatic damage caused by coxsackievirus B3 is dependent on age-related tissue tropisms associated with the coxsackievirus-adenovirus receptor (pages 52–60)

      Jung-Yen Liu, Shih-Min Wang, I-Chun Chen, Chun-Keung Yu and Ching-Chuan Liu

      Version of Record online: 7 JUN 2013 | DOI: 10.1111/2049-632X.12044

      This study brings a novel angle on coxsackievirus B (CVB) pathogenesis, as most of the previous studies have focused on heart or pancreas disease. Here, it is shown that infection by the human isolate CVB3 results in hepatocyte necrosis and apoptosis. The role of the viral receptor CAR is also studied, and amelioration of the symptoms after treatment with anti-CAR antibody is demonstrated, thus hinting at the potential importance of targeting CAR for therapeutic development.

    3. Short Communication

      Resveratrol role in Staphylococcus aureus-induced corneal inflammation (pages 61–64)

      Andreana Marino, Giuseppe Santoro, Francesca Spataro, Eugenia R. Lauriano, Simona Pergolizzi, Francesco Cimino, Antonio Speciale, Antonia Nostro, Giuseppe Bisignano and Giacomo Dugo

      Version of Record online: 3 JUN 2013 | DOI: 10.1111/2049-632X.12046

      Corneal inflammatory diseases are often associated to Staphylococcus aureus (limbitis, blepharo-conjunctivitis, superficial punctate keratopathy, staphylococcal marginal keratitis, and corneal abscesses). Except for corneal abscesses, S. aureus induced corneal inflammation seems to be related to host hypersensitivity rather than to a classical invasive infection. This new approach targeting the immune-modulation of the corneal epithelium seems to be an attractive alternative solution to conventional treatment consisting of corticosteroid drops.

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