Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities (pages 116–124)
Francesca Esposito, Cinzia Sanna, Claudia Del Vecchio, Valeria Cannas, Alessandro Venditti, Angela Corona, Armandodoriano Bianco, Anna M. Serrilli, Laura Guarcini, Cristina Parolin, Mauro Ballero and Enzo Tramontano
Article first published online: 2 JUL 2013 | DOI: 10.1111/2049-632X.12051
Combination antiretroviral therapy has forever changed the outcome of AIDS, transforming it from an untreatable, fatal syndrome into a manageable chronic condition. However, the search for new therapeutic targets is always on, because of the issue of mutation in the virus determining resistance to all drugs in use. Esposito et al. describe the activities of compounds that they tested against RNase H, a viral enzyme that has not been fully exploited as a target for antiretrovirals. Their results will be relevant to the development of new drugs to treat HIV infection.