Pathogens and Disease

Cover image for Vol. 67 Issue 1

February 2013

Volume 67, Issue 1

Pages i–ii, 1–88

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. Issue Information (pages i–ii)

      Version of Record online: 12 FEB 2013 | DOI: 10.1111/j.1574-695X.2012.01015.x

  2. Editorial

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
  3. Letter to the Editor

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. Why was Desulfovibrio fairfieldensis not found in faecal DNA from patients with gastric disease? (page 3)

      Wenjing Jia, Matthew Faulkner, Ian Cadby and Jeff Cole

      Version of Record online: 10 JAN 2013 | DOI: 10.1111/2049-632X.12013

  4. Molecular Pathogenesis

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. Research Article

      Lack of antigenic diversification of major outer membrane proteins during clonal waves of Neisseria meningitidis serogroup A colonization and disease (pages 4–10)

      Charlotte A. Huber, Valentin Pflüger, Abdul-Wahab M. Hamid, Abudulai A. Forgor, Abraham Hodgson, Ali Sié, Thomas Junghanss and Gerd Pluschke

      Version of Record online: 28 NOV 2012 | DOI: 10.1111/2049-632X.12000

      This very interesting study compares outer membrane protein sequences in a number of Neisseria meningitidis serogroup.A disease and carriage isolates from a defined region or subsaharan Africa between 2002 and 2008. It concludes that there is a remarkable antigenic stability in this population and that herd immunity is not a strong driving force for antigenic diversification. The study is well conceived and carried out, the results are clearly presented and the conclusions pertinent.This is important and useful information

    2. Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol (pages 11–18)

      Shan Li, Lianfa Shi, Zhiyong Yang and Hanping Feng

      Version of Record online: 14 JAN 2013 | DOI: 10.1111/2049-632X.12016

      This is an excellent, paradigm-shifting in Clostridium difficile toxin-mediated pathogenesis. The data are excellent.

    3. Staphylococcus aureus mutants lacking cell wall-bound protein A found in isolates from bacteraemia, MRSA infection and a healthy nasal carrier (pages 19–24)

      Marit Sørum, Maria Sangvik, Marc Stegger, Renate S. Olsen, Mona Johannessen, Robert Skov and Johanna U. E. Sollid

      Version of Record online: 10 JAN 2013 | DOI: 10.1111/2049-632X.12017

      Truncated SpA, not anchored to the cell wall, can still be found during carriage or infection, underlining the fact that there is no single virulence factor in Staphylococcus aureus that is required for generating a specific type of infection

  5. Microbial Communities in Infection and Disease

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. MiniReview

      Microbial biofilms and gastrointestinal diseases (pages 25–38)

      Erik C. von Rosenvinge, Graeme A. O'May, Sandra Macfarlane, George T. Macfarlane and Mark E. Shirtliff

      Version of Record online: 29 JAN 2013 | DOI: 10.1111/2049-632X.12020

      This timely review on the significance of microbial biofilms and gastrointestinal disease will stimulate research in this field.

    2. Research Article

      Eradication of Pseudomonas aeruginosa biofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination (pages 39–45)

      Gregory G. Anderson, Thomas F. Kenney, David L. MacLeod, Noreen R. Henig and George A. O'Toole

      Version of Record online: 10 JAN 2013 | DOI: 10.1111/2049-632X.12015

      This is an interesting study where Pseudomonas aeruginosa biofilms were grown on CF airway epithelial cells to study the synergistic effect of Fosfomycin/Fobramycin formulas (FTI) for Inhalation treatment of infection on biofilm formation. FTI holds promise for treatment of chronic airway infection and in this work it is clear that there is a significant effect on biofilm formation under in vivo like conditions investigated.

  6. Host Responses to Infection

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. MiniReview

      Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa (pages 46–53)

      Jessica Shiu and Thomas G. Blanchard

      Version of Record online: 22 JAN 2013 | DOI: 10.1111/2049-632X.12014

      This MiniReview concisely summarizes the evidence that dendritic cells play an important role in modulating T cell responses to Helicobacter pylori infection, primarily through the development of regulatory T (Treg) cells, which may limit the gastritis associated with this infection.

    2. Research Article

      Cord-forming mycobacteria induce DNA meshwork formation by human peripheral blood mononuclear cells (pages 54–66)

      Bodil E. Jönsson, Johan Bylund, Bengt R. Johansson, Esbjörn Telemo and Agnes E. Wold

      Version of Record online: 15 NOV 2012 | DOI: 10.1111/2049-632X.12007

      This study investigates the response of human blood mononuclear cells (PBMCs) to a cord-forming strain of Mycobacterium abscessus. A fibrous chromatin-like meshwork containing DNA and histones is produced by the PBMCs,perhaps as a defense mechanism against other invaders. Overall very nicely done and with well-illustrated results.

  7. Omics and Systems Biology

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. Research Article

      Time-course proteomic profile of Candida albicans during adaptation to a fetal serum (pages 67–75)

      Wataru Aoki, Tomomi Ueda, Yohei Tatsukami, Nao Kitahara, Hironobu Morisaka, Kouichi Kuroda and Mitsuyoshi Ueda

      Version of Record online: 20 NOV 2012 | DOI: 10.1111/2049-632X.12003

      This work uses state-of-the-art proteomics methodology (LC-MS/MS) to examine the growth of the important pathogen,Candida albicans, as it adapts to fetal serum. They identify several proteins that may be candidate virulence factors.

  8. Translational Research

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Letter to the Editor
    5. Molecular Pathogenesis
    6. Microbial Communities in Infection and Disease
    7. Host Responses to Infection
    8. Omics and Systems Biology
    9. Translational Research
    1. Research Article

      Green tea epigallocatechin-3-gallate attenuates Porphyromonas gingivalis-induced atherosclerosis (pages 76–83)

      Yu Cai, Tomoko Kurita-Ochiai, Tomomi Hashizume and Masafumi Yamamoto

      Version of Record online: 15 NOV 2012 | DOI: 10.1111/2049-632X.12001

      This is a very interesting and relevant study that demonstrates the ability of epigallocatechin-3-gallate (EGCG), a polyphenol extract from green tea, to protect against Porphyromonas gingivalis-induced atherosclerosis. The experimental approach is straightforward and the results provide evidence for the mechanism accounting for the protective effect.

    2. Short Communication

      Alterations of penicillin-binding proteins in pneumococci with stepwise increase in β-lactam resistance (pages 84–88)

      Yu-Chia Hsieh, Lin-Hui Su, Mei-Hua Hsu and Cheng-Hsun Chiu

      Version of Record online: 4 FEB 2013 | DOI: 10.1111/2049-632x.12018

      This paper provides a comprehensive database of penicillin-binding protein mutations associated with b-lactam resistance in Streptococcus pneumoniae.

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