Pathogens and Disease

Cover image for Vol. 69 Issue 2

Special Issue: Coinfections Issue Editors: Hans-Dieter Klenk, Eliora Ron, Philippe Sansonetti, Tone Tønjum

November 2013

Volume 69, Issue 2

Pages i–ii, 71–158

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Editorial
    4. MiniReviews
    5. Research Articles
    6. Short Communication
    1. Issue Information (pages i–ii)

      Version of Record online: 22 OCT 2013 | DOI: 10.1111/j.1574-695X.2013.01022.x

  2. Editorial

    1. Top of page
    2. Issue Information
    3. Editorial
    4. MiniReviews
    5. Research Articles
    6. Short Communication
    1. You have free access to this content
      The synergies of microorganisms enlightened – convergent approaches to delineating coinfections (page 71)

      Hans-Dieter Klenk, Eliora Ron, Philippe Sansonetti and Tone Tønjum

      Version of Record online: 22 OCT 2013 | DOI: 10.1111/2049-632X.12101

  3. MiniReviews

    1. Top of page
    2. Issue Information
    3. Editorial
    4. MiniReviews
    5. Research Articles
    6. Short Communication
    1. Host Organelle Hijackers: a similar modus operandi for Toxoplasma gondii and Chlamydia trachomatis: co-infection model as a tool to investigate pathogenesis (pages 72–86)

      Julia D. Romano and Isabelle Coppens

      Version of Record online: 22 JUL 2013 | DOI: 10.1111/2049-632X.12057

      This mini-review is very well written on a unique topic. The figures are very nice. The article is also quite timely as it integrates basic concepts in the mechanisms used by two evolutionarily divergent organisms, Toxoplasma and Chlamydia, that commonly develop within the host cell.

    2. You have free access to this content
      Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium (pages 87–100)

      Eva Böttcher-Friebertshäuser, Hans-Dieter Klenk and Wolfgang Garten

      Version of Record online: 2 JUL 2013 | DOI: 10.1111/2049-632X.12053

      The authors, who are leading experts in this field, present a timely, authoritative review on the proteolytic cleavage of the influenza hemagglutinin (HA), an activation mechanism that is essential for the infectivity of influenza viruses, including the recently emerged H7N9. They also address the potential of host proteases as targets for developing new influenza drugs. This review will be of considerable interest to virologists, microbiologists and pharmaceutical companies alike.

    3. Co-infection with Mycobacterium tuberculosis and human immunodeficiency virus: an overview and motivation for systems approaches (pages 101–113)

      Armin Deffur, Nicola J. Mulder and Robert J. Wilkinson

      Version of Record online: 17 JUL 2013 | DOI: 10.1111/2049-632X.12060

      The authors present a thorough review of knowledge about the interaction of HIV and tuberculosis from several perspectives, including clinical, immunological and epidemiological perspectives. This review is very enjoyable to read and very informative for all those interested in HIV and/or tuberculosis.

    4. Haemophilus influenzae and Streptococcus pneumoniae: living together in a biofilm (pages 114–126)

      Alexandra Tikhomirova and Stephen P. Kidd

      Version of Record online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12073

      Bacterial opportunists including Haemophilus influenzae and Streptococcus pneumoniae frequently reside in the nasopharynx of healthy children from where it can migrate to cause severe infections involving lungs middle ear and the brain. It is now clear that biofilms promote bacterial persistence during many of these infections. This MiniReview nicely summarizes a large amount of work on Haemophilus and pneumococcus in biofilms alone and in co-culture.

    5. You have full text access to this OnlineOpen article
      Helminths and their implication in sepsis – a new branch of their immunomodulatory behaviour? (pages 127–141)

      Marc P. Hübner, Laura E. Layland and Achim Hoerauf

      Version of Record online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12080

      This well written review gives a comprehensive overview on the immunopathology of sepsis and the modulation of immune responses by helminths. It provides evidence that helminths or components thereof may improve the outcome of severe infections. This will allow the development of therapeutic strategies to fight infections and sepsis.

  4. Research Articles

    1. Top of page
    2. Issue Information
    3. Editorial
    4. MiniReviews
    5. Research Articles
    6. Short Communication
    1. Pseudomonas aeruginosa-dependent upregulation of TLR2 influences host responses to a secondary Staphylococcus aureus infection (pages 149–156)

      Hee-Sung Shin, Jung-Hoon Lee, Se-Hwan Paek, Yong Woo Jung and Un-Hwan Ha

      Version of Record online: 2 SEP 2013 | DOI: 10.1111/2049-632X.12074

      The clinical impact of polymicrobial infections has increasingly recognized in recent years. In this study the impact of a P. aeruginosa infection on a secondary S. aureus was studied. The findings are intriguing since it was demonstrated that the primary P. aeruginosa infection upregulated TLR2 expression thereby enhancing innate immune responses against the secondary S. aureus infection.

  5. Short Communication

    1. Top of page
    2. Issue Information
    3. Editorial
    4. MiniReviews
    5. Research Articles
    6. Short Communication
    1. You have full text access to this OnlineOpen article
      Dientamoeba fragilis DNA detection in Enterobius vermicularis eggs (pages 157–158)

      Jessica Ögren, Olaf Dienus, Sture Löfgren, Peter Iveroth and Andreas Matussek

      Version of Record online: 12 AUG 2013 | DOI: 10.1111/2049-632X.12071

      This paper describes a protocol to wash and surface-sterilize E. vermicularis eggs, with the aim of showing presence of both E. vermicularis and D. fragilis specific DNA within, and the results from 20 co-infected patients. The study has merit as a confirmatory study of the trials by Röser et al. (2013), and includes improvements of the protocol.

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