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Pathogens and Disease

Cover image for Vol. 70 Issue 1

February 2014

Volume 70, Issue 1

Pages i–iii, 1–98

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
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      Issue Information (pages i–iii)

      Article first published online: 12 FEB 2014 | DOI: 10.1111/2049-632X.12087

  2. Editorial

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. You have free access to this content
  3. Microbial Communities in Infection and Disease

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. MiniReview

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      Alterations in TLRs as new molecular markers of congenital infections with Human cytomegalovirus? (pages 3–16)

      Wioletta Wujcicka, Jan Wilczyński and Dorota Nowakowska

      Article first published online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12083

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      The study presents the activity of TLRs and their SNPs in the immunity to HCMV infections and in pregnancy and shows plausible involvement of TLR alterations in congenital cytomegaly development.

  4. Host responses to Infection

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Research Articles

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      Interaction of Cryptosporidium parvum with mouse dendritic cells leads to their activation and parasite transportation to mesenteric lymph nodes (pages 17–27)

      Gregorio Perez-Cordon, Guilin Yang, Boping Zhou, Weijia Nie, Shan Li, Lianfa Shi, Saul Tzipori and Hanping Feng

      Article first published online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12078

      Thumbnail image of graphical abstract

      This report documents the role of dendritic cells in Cryptosporidium infections.

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      Mycobacterium tuberculosis escapes from the phagosomes of infected human osteoclasts reprograms osteoclast development via dysregulation of cytokines and chemokines (pages 28–39)

      Akiyoshi Hoshino, Sanshiro Hanada, Hiroyuki Yamada, Shinji Mii, Masahide Takahashi, Satoshi Mitarai, Kenji Yamamoto and Yoshinobu Manome

      Article first published online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12082

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      Intracellular Mtb infection in multinuclear osteoclasts reprograms osteoclast development via the dysregulation of cytokines and chemokines.

  5. Host Responses to Infection

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Research Articles

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      Human antibody responses to pneumococcal surface protein A and capsular polysaccharides during acute and convalescent stages of invasive disease in adult patients (pages 40–50)

      Jan Kolberg, Audun Aase, Lisbeth M. Næss, Ingeborg S. Aaberge and Dominique A. Caugant

      Article first published online: 21 NOV 2013 | DOI: 10.1111/2049-632X.12106

      There are few reports on the analyses of human IgG antibody responses to both capsular polysaccharides and pneumococcal surface protein A (PspA). Using flow cytometry for assay of antibody binding to the patient's own isolate (live pneumococci), we found that the PspA antigens might be less important for development of protective antibodies than capsular polysaccharides. Low levels of serotype specific antibodies in the patients acute phase sera, may reflect why they were not protected.

  6. Molecular Pathogenesis

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Research Articles

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      The RD1 locus in the Mycobacterium tuberculosis genome contributes to the maturation and secretion of IL-1α from infected macrophages through the elevation of cytoplasmic calcium levels and calpain activation (pages 51–60)

      Ruili Yang, Chen Xi, Dewamitta R. Sita, Shunsuke Sakai, Kohsuke Tsuchiya, Hideki Hara, Yanna Shen, Huixin Qu, Rendong Fang, Masao Mitsuyama and Ikuo Kawamura

      Article first published online: 23 AUG 2013 | DOI: 10.1111/2049-632X.12075

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      A series of in vitro experiments show that release of mature IL-1α by macrophages following a Mycobacterium tuberculosis infection is dependent on RD1.

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      Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model (pages 61–69)

      Ira M. Sigar, Justin H. Schripsema, Yibing Wang, Ian N. Clarke, Lesley T. Cutcliffe, Helena M.B. Seth-Smith, Nicholas R. Thomson, Carina Bjartling, Magnus Unemo, Kenneth Persson and Kyle H. Ramsey

      Article first published online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12086

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      The chlamydial plasmid was found to enhance infectivity and virulence in a mouse model.

    3. Short Communication

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      Role of the Listeria monocytogenes 2-Cys peroxiredoxin homologue in protection against oxidative and nitrosative stress and in virulence (pages 70–74)

      Lone E. Dons, Ahmed Mosa, Martin E. Rottenberg, Jesper T. Rosenkrantz, Krister Kristensson and John E. Olsen

      Article first published online: 12 SEP 2013 | DOI: 10.1111/2049-632X.12081

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      In this article the authors studied the role of a 2-Cys peroxiredoxin (Prx) homologue in Listeria monocytogenes, an intracellular bacterial pathogen. They found that Prx contributes to resistance against reactive oxygen and nitrogen intermediates, and also to virulence in wild type mice but not in iNOS-deficient mice, demonstrating the importance of this factor.

  7. Omics and Systems Biology

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Research Article

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      Identification of a protective protein from stationary-phase exoproteome of Brucella abortus (pages 75–83)

      Shikha Jain, Subodh Kumar, Sudhir Dohre, Prachiti Afley, Nabonita Sengupta and Syed I. Alam

      Article first published online: 14 AUG 2013 | DOI: 10.1111/2049-632X.12079

      A human vaccine for brucellosis is needed and ribosomal protein L9 protein reported in this work could be a good candidate.

  8. Shortomics

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Short Communication

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      Mass spectrometry-based proteomic analysis of Leishmania donovani soluble proteins in Indian clinical isolate (pages 84–87)

      Awanish Kumar, Pragya Misra, Brijesh Sisodia, Ajit Kumar Shasany, Shyam Sundar and Anuradha Dube

      Article first published online: 5 NOV 2013 | DOI: 10.1111/2049-632X.12103

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      Identified novel proteins may offer increased hope for promising new drug/vaccine targets for disease management.

  9. Translational Research

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Research Article

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      A synthetic lymph node containing inactivated Treponema pallidum cells elicits strong, antigen-specific humoral and cellular immune responses in mice (pages 88–94)

      Lola V. Stamm and Rebecca L. Drapp

      Article first published online: 7 OCT 2013 | DOI: 10.1111/2049-632X.12098

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      This study shows that a strong immune response to Treponema pallidum, the syphilis agent, was elicited in mice via the use of a novel strategy that employed a synthetic lymph node.

  10. Virulence Factors

    1. Top of page
    2. Issue Information
    3. Editorial
    4. Microbial Communities in Infection and Disease
    5. Host responses to Infection
    6. Host Responses to Infection
    7. Molecular Pathogenesis
    8. Omics and Systems Biology
    9. Shortomics
    10. Translational Research
    11. Virulence Factors
    1. Short Communication

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      Gallium induces the production of virulence factors in Pseudomonas aeruginosa (pages 95–98)

      Rodolfo García-Contreras, Berenice Pérez-Eretza, Elizabeth Lira-Silva, Ricardo Jasso-Chávez, Rafael Coria-Jiménez, Adrián Rangel-Vega, Toshinari Maeda and Thomas K. Wood

      Article first published online: 14 NOV 2013 | DOI: 10.1111/2049-632X.12105

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      Gallium, a novel antimicrobial, interferes with iron homeostasis in Pseudomonas aeruginosa. However, iron deficiency increases virulence, and we found gallium also increases the production of virulence factors in laboratory and clinical strains.

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