Pathogens and Disease

Cover image for Vol. 70 Issue 2

March 2014

Volume 70, Issue 2

Pages i–ii, 99–202

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Host Responses to Infection
    4. Molecular Pathogenesis
    5. Virulence Factors
    6. Corrigendum
    1. Issue Information (pages i–ii)

      Article first published online: 14 MAR 2014 | DOI: 10.1111/2049-632X.12088

  2. Host Responses to Infection

    1. Top of page
    2. Issue Information
    3. Host Responses to Infection
    4. Molecular Pathogenesis
    5. Virulence Factors
    6. Corrigendum
    1. MiniReviews

      The route less taken: pulmonary models of enteric Gram-negative infection (pages 99–109)

      Michael L. Fisher, Wei Sun and Roy Curtiss III

      Article first published online: 21 NOV 2013 | DOI: 10.1111/2049-632X.12109

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      Reviewing pulmonary routes of infection to elucidate mechanisms of pathogenesis in host restricted, enteric pathogens.

    2. HIV–Mycobacterium tuberculosis co-infection: a ‘danger-couple model’ of disease pathogenesis (pages 110–118)

      Esaki M. Shankar, Ramachandran Vignesh, Rada Ellegård, Muttiah Barathan, Yee K. Chong, M. Kahar Bador, Devi V. Rukumani, Negar S. Sabet, Adeeba Kamarulzaman, Vijayakumar Velu and Marie Larsson

      Article first published online: 25 NOV 2013 | DOI: 10.1111/2049-632X.12108

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      The immunopathogenesis underlying the symbiotic establishment of HIV-1/M. tuberculosis in the susceptible host remains to be understood better to design strategies ultimately to improve the quality of life of infected individuals.

    3. Research Articles

      Evaluation of YadC protein delivered by live attenuated Salmonella as a vaccine against plague (pages 119–131)

      Wei Sun, Joseph Olinzock, Shifeng Wang, Shilpa Sanapala and Roy Curtiss 3rd

      Article first published online: 10 SEP 2013 | DOI: 10.1111/2049-632X.12076

      Mice immunized with Salmonella vector delivering YadC were afforded partial protection against bubonic plague challenge.

    4. Inhibition of toll-like receptor 2 (TLR-2)-mediated response in human alveolar epithelial cells by mycolic acids and Mycobacterium tuberculosis mce1 operon mutant (pages 132–140)

      Patricia C. Sequeira, Ryan H. Senaratne and Lee W. Riley

      Article first published online: 16 DEC 2013 | DOI: 10.1111/2049-632X.12110

      A type of fatty acid called mycolic acid made by the bacteria that causes TB inhibits lung cell function, which may ultimately determine if someone gets TB or not.

    5. Transcriptional profiling of recall responses to Francisella live vaccine strain (pages 141–152)

      Chrysanthi Paranavitana, Luis DaSilva, Antoaneta Vladimirova, Phillip R. Pittman, Mahendran Velauthapillai and Mikeljon Nikolich

      Article first published online: 23 JAN 2014 | DOI: 10.1111/2049-632X.12113

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      Transcriptional profiling of recall responses to Francisella live vaccine strain

    6. Short Communication

      Murine marginal zone B cells play a role in Vibrio cholerae LPS antibody responses (pages 153–157)

      William F. Wade, R. Glenn King, Cyrille Grandjean, Terri K. Wade and Louis B. Justement

      Article first published online: 12 SEP 2013 | DOI: 10.1111/2049-632X.12085

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      New perspectives are needed to build a universal cholera vaccine.

  3. Molecular Pathogenesis

    1. Top of page
    2. Issue Information
    3. Host Responses to Infection
    4. Molecular Pathogenesis
    5. Virulence Factors
    6. Corrigendum
    1. Research Articles

      Staphylococcus aureus nasal isolates from healthy individuals cause highly variable host cell responses in vitro: The Tromsø Staph and Skin Study (pages 158–166)

      Fatemeh Askarian, Maria Sangvik, Anne-Merethe Hanssen, Lars Snipen, Johanna U.E. Sollid and Mona Johannessen

      Article first published online: 11 OCT 2013 | DOI: 10.1111/2049-632X.12099

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      Staphylococcus aureus isolates from healthy hosts are phenotypically diverse and causes highly variable host cell responses. Therefore, generalizing the results from one S. aureus isolate to all is highly questionable.

    2. Invasion of differentiated intestinal Caco-2 cells is a sporadic property among atypical enteropathogenic Escherichia coli strains carrying common intimin subtypes (pages 167–175)

      Veronica C.R. Pacheco, Denise Yamamoto, Cecilia M. Abe, Rodrigo T. Hernandes, Azucena Mora, Jorge Blanco and Tânia A.T. Gomes

      Article first published online: 16 DEC 2013 | DOI: 10.1111/2049-632X.12112

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      This study shows that enterocyte invasiveness in vitro is a sporadic property among atypical enteropathogenic Escherichia coli strains carrying some common intimin subtypes (alpha, beta and gamma).

    3. Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity (pages 176–184)

      Christopher G. Earnhart, DeLacy V. L. Rhodes, Alexis A. Smith, Xiuli Yang, Brittney Tegels, Jason A. Carlyon, Utpal Pal and Richard T. Marconi

      Article first published online: 3 FEB 2014 | DOI: 10.1111/2049-632X.12119

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      This study is among the first to directly investigate the potential contribution of specific domains of OspC in vivo using the tick-mouse model for Lyme disease.

    4. Short Communications

      Identification and characterization of a novel inhibitor of alginate overproduction in Pseudomonas aeruginosa (pages 185–188)

      T. Ryan Withers, Yeshi Yin and Hongwei D. Yu

      Article first published online: 5 NOV 2013 | DOI: 10.1111/2049-632X.12102

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      We report identification and characterization of a novel inhibitor of a mucoid biofilm produced by laboratory and clinical strains of Pseudomonas aeruginosa with a wild type MucA.

    5. Plasmid-mediated transformation tropism of chlamydial biovars (pages 189–193)

      Lihua Song, John H. Carlson, Bing Zhou, Kimmo Virtaneva, William M. Whitmire, Gail L. Sturdevant, Stephen F. Porcella, Grant McClarty and Harlan D. Caldwell

      Article first published online: 11 NOV 2013 | DOI: 10.1111/2049-632X.12104

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      This study is the first to show that plasmid mediated transformation of chlamydiae is biovar-specific; a tropism that provides experimental evidence for a co-evolutionary relationship between plasmid and chromosomal genes.

  4. Virulence Factors

    1. Top of page
    2. Issue Information
    3. Host Responses to Infection
    4. Molecular Pathogenesis
    5. Virulence Factors
    6. Corrigendum
    1. Research Article

      Invasive hypermucoid variant of group A Streptococcus is defective in growth and susceptible to DNA-damaging treatments (pages 194–201)

      Chuan Chiang-Ni, Po-Xing Zheng, Shuying Wang, Pei-Jane Tsai, Chih-Feng Kuo, Woei-Jer Chuang, Yee-Shin Lin, Ching-Chuan Liu and Jiunn-Jong Wu

      Article first published online: 16 DEC 2013 | DOI: 10.1111/2049-632X.12114

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      By parallel comparison of the phenotypes of mucoid (less invasvie) and hypermucoid (more invasive) variants, our results suggest that the susceptible to DNA-damaging treatments is an adverse factor for hypermucoid variant inhibiting its adaptation to the host environment.

  5. Corrigendum

    1. Top of page
    2. Issue Information
    3. Host Responses to Infection
    4. Molecular Pathogenesis
    5. Virulence Factors
    6. Corrigendum
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