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gbb12035-sup-0001-FigureS1.docWord document561KFigure S1: Statistical parametric map illustrating task-related activation FWE-corrected across the entire brain (maximal voxel in left hemisphere: x = −12, y = 6, z = −10, t = 8.27, P = 7.72 × 10−9, kE = 382; right hemisphere: x = 12, y = 10, z = −8, t = 8.23, P = 9.41 × 10−9, kE = 205). Activation clusters are overlaid onto canonical structural brain images and displayed at coordinates x = 12, y = 16, z = −8. Color bar represents t values.
gbb12035-sup-0002-FigureS2.docWord document282KFigure S2: Bilateral VS anatomical mask (bilateral sphere with 10 mm radius built around x = ±12, y = 12, z = −10) overlaid onto canonical structural brain images at coordinates: x = 12, y = 12, z = −10.
gbb12035-sup-0003-TableS1.docWord document37KTable S1: Number of participants meeting criteria for DSM-IV Axis I diagnoses.
gbb12035-sup-0004-TableS2.docWord document53KTable S2: Gender differences in individual AUDIT items. Men reported higher scores on items associated with frequency and quantity of alcohol consumption, as well as overall hazardous drinking patterns. No gender differences emerged on items associated with guilt or dependence. Items which differed significantly between genders are presented in bold. The Greenhouse–Geisser correction was used whenever Levene's test for equality of variances was significant.
gbb12035-sup-0005-TableS3.docWord document39KTable S3: Moderated mediation model results specifying the parameter estimates along with the bootstrapped bias-corrected 95% confidence intervals for the gender-specific indirect effects of GAL genotype on drinking scores via VS reactivity in the left hemisphere.
gbb12035-sup-0006-TableS4.docWord document42KTable S4: Moderated mediation model results specifying the parameter estimates along with the bootstrapped bias-corrected 95% confidence intervals for the gender-specific indirect effects of GAL genotype on drinking scores via VS reactivity in the left and right hemisphere, when participants meeting criteria for cannabis abuse (n = 1) and cannabis dependence (n = 1) were excluded from the analyses.
gbb12035-sup-0007-TableS5.docWord document30KTable S5: Moderated mediation model results specifying the parameter estimates along with the bootstrapped bias-corrected 95% confidence intervals for the gender-specific indirect effects of GAL genotype on drinking scores via VS reactivity in the left and right hemisphere, when smoking status was controlled for alongside age and current Axis I diagnosis.
gbb12035-sup-0008-TableS6.docWord document42KTable S6: Moderated mediation model results specifying the parameter estimates along with the bootstrapped bias-corrected 95% confidence intervals for the gender-specific indirect effects of GAL genotype on CES-D scores via VS reactivity in the left and right hemisphere. There are no significant effects.

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