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gbb12092-sup-0001-FigureS1.tifTIFF image1488KFigure S1: Gene expression networks associated with male midbrain 5-HT traits. Genes (top 25) with highest correlations with (a) 5-HT, (b) 5-HIAA or (c) 5-HT turnover (TO, 5-HIAA/5-HT) are graphed separately based on the direction of correlation (green: positive; red: negative). Gene node sizes and colors represent the significance of correlation. Gene pairs with correlation coefficients (Spearman's rho) above 0.5 are connected by edges (green: positive; red: negative).
gbb12092-sup-0002-FigureS2.tifTIFF image2528KFigure S2: Gene expression networks associated with determinants of midbrain 5-HT synthesis, metabolism and inactivation. Genes (top 25) with highest correlations with (a) Gch1, (b) Maoa or (c) Slc18a2 are graphed separately based on the direction of correlation (green: positive; red: negative). Gene node sizes and colors represent the significance of correlation. Gene pairs with correlation coefficients (Spearman's rho) above 0.5 are connected by edges (green: positive; red: negative).
gbb12092-sup-0003-TableS1.docWord document144KTable S1: Analysis of heritability of male blood, midbrain and diencephalon 5-HT traits. Numbers in parentheses designate the number of strains used in calculations. P values are calculated using one-way anova F-test. Adjusted heritabilities (h2) are calculated using Hegmann and Possidente's method.
gbb12092-sup-0004-TableS2.docWord document144KTable S2: Analysis of gender effects in female blood, midbrain and diencephalon serotonergic traits. Numbers in parentheses designate the number of strains used in calculations. P values are calculated using one-way anova F-test. Adjusted heritabilities (h2) are calculated using Hegmann and Possidente's method.
gbb12092-sup-0005-AppendixS1.xlsxExcel 2007 spreadsheet69KAppendix S1: Animals used in this study. Number of animals and their genders from each BXD strain are listed for each experiment. Highlighted BXD strains represent lines that both 5-HT traits and midbrain transcriptome data were obtained.
gbb12092-sup-0006-AppendixS2.xlsxExcel 2007 spreadsheet288KAppendix S2: Archived BXD phenotypes that have significant correlations with measured serotonergic traits separated by genders (P < 0.05, Spearman's rank test).
gbb12092-sup-0007-AppendixS3.xlsxExcel 2007 spreadsheet71KAppendix S3: Archived BXD phenotypes that have significant correlations with midbrain 5-HT levels (gender pooled, P < 0.05, Spearman's rank test).
gbb12092-sup-0008-AppendixS4.xlsxExcel 2007 spreadsheet67KAppendix S4: Archived BXD phenotypes that have significant correlations with blood 5-HT levels (gender pooled, P < 0.05, Spearman's rank test).
gbb12092-sup-0009-AppendixS5.xlsxExcel 2007 spreadsheet61KAppendix S5: Genes located under the quantitative loci identified by the interval mapping of midbrain 5-HT levels. Confidence interval for each QTL peak was determined by 1.5 LOD dropoff method.
gbb12092-sup-0010-AppendixS6.xlsxExcel 2007 spreadsheet54KAppendix S6: Genes located under the quantitative loci identified by the interval mapping of blood 5-HT levels. Confidence interval for each QTL peak was determined by 1.5 LOD dropoff method.
gbb12092-sup-0011-AppendixS7.xlsxExcel 2007 spreadsheet269KAppendix S7: Lists of genes whose midbrain expression significantly correlated with midbrain 5-HT traits (P < 0.05, Spearman's rank test).
gbb12092-sup-0012-AppendixS8.xlsxExcel 2007 spreadsheet49KAppendix S8: Lists of overlapping genes whose expression correlated with midbrain 5-HT traits and (1) exhibit similar anatomical expression pattern defined by Tph2 and Slc6a4 using NeuroBlast or (2) demonstrated enrichment in E12.5 developing 5-HT neurons. Original gene lists are also included as separate sheets.
gbb12092-sup-0013-AppendixS9.xlsxExcel 2007 spreadsheet281KAppendix S9: Lists of genes whose midbrain expression significantly correlated with diencephalon 5-HT traits (P < 0.05, Spearman's rank test).
gbb12092-sup-0014-AppendixS10.xlsxExcel 2007 spreadsheet32KAppendix S10: List of genes identified by interval mapping of midbrain 5-HT levels filtered by their expression correlation with midbrain 5-HT traits. Each gene's expression in the raphe nuclei was scored by visual inspection of in situ data set from Allen Brain Atlas (N/A: probe not available or signal not strong enough).

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