gbb12098-sup-0001-FigureS1.docWord document84KFigure S1: Experimental design and sampling points for study animals. All mice were weaned at 21 days of age and placed into their respective diet and wheel groups at approximately 24 days old. Running data were recorded daily but analyzed in weekly or biweekly segments. Body mass, blood and food hopper mass were taken at the end of each ‘Runday’ segment at noon and the new segment started immediately thereafter. For example, Mass2 and blood sample 2 were measured on Runday 8 at noon followed by the start of Runday 9. The variable ‘Ate’ represents the total food consumption (grams) consumed during the indicated period. For analyses of food consumption, food mass was converted to kilojoules per day using the metabolizable energy for each diet (see Materials and methods).
gbb12098-sup-0002-FigureS2.docWord document166KFigure S2: Least-squares means and standard errors for wheel running for both C and HR mice on both diets averaged over the entire experiment. The HR mice ran substantially more than C mice when on standard diet, but this differential was greatly increased on Western diet (i.e. there was a highly significant linetype × diet interaction).
gbb12098-sup-0003-TableS1.docWord document57KTable S1: P values from analysis of variance (anova) or analysis of covariance (ancova) for body mass.
gbb12098-sup-0004-TableS2.docWord document35KTable S2: P values from ancovas for organ masses with body length (nose-rump) and caloric intake as covariates.
gbb12098-sup-0005-TableS3.docWord document40KTable S3: F and P values from ancovas for log-transformed caloric intake (kJ/day).
gbb12098-sup-0006-TableS4.docWord document34KTable S4: P values from ancova for fasting plasma metabolites.

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