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  • Adkins, R.M., Krushkal, J., Tylavsky, F.A. & Thomas, F. (2011) Racial differences in gene-specific DNA methylation levels are present at birth. Birth Defects Res A Clin Mol Teratol 91, 728736.
  • Amatori, S., Bagaloni, I., Donati, B. & Fanelli, M. (2010) DNA demethylating antineoplastic strategies: a comparative point of view. Genes Cancer 1, 197209.
  • American Psychiatric Association. (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington, VA.
  • Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U. & Zoghbi, H.Y. (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat Genet 23, 185188.
  • Appleton, K., Mackay, H.J., Judson, I., Plumb, J.A., McCormick, C., Strathdee, G., Lee, C., Barrett, S., Reade, S., Jadayel, D., Tang, A., Bellenger, K., Mackay, L., Setanoians, A., Schatzlein, A., Twelves, C., Kaye, S.B. & Brown, R. (2007) Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J Clin Oncol 25, 46034609.
  • Baylin, S.B. & Herman, J.G. (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16, 168174.
  • Beach, S.R., Brody, G.H., Todorov, A.A., Gunter, T.D. & Philibert, R.A. (2010) Methylation at SLC6A4 is linked to family history of child abuse: an examination of the Iowa Adoptee sample. Am J Med Genet B Neuropsychiatr Genet 153B, 710713.
  • Bhutani, N., Brady, J.J., Damian, M., Sacco, A., Corbel, S.Y. & Blau, H.M. (2010) Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463, 10421057.
  • Binder, E.B., Bradley, R.G., Liu, W., Epstein, M.P., Deveau, T.C., Mercer, K.B., Tang, Y., Gillespie, C.F., Heim, C.M., Nemeroff, C.B., Schwartz, A.C., Cubells, J.F. & Ressler, K.J. (2008) Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299, 12911305.
  • Bjornsson, H.T., Fallin, M.D. & Feinberg, A.P. (2004) An integrated epigenetic and genetic approach to common human disease. Trends Genet 20, 350358.
  • Blechert, J., Michael, T., Vriends, N., Margraf, J. & Wilhelm, F.H. (2007) Fear conditioning in posttraumatic stress disorder: evidence for delayed extinction of autonomic, experiential, and behavioural responses. Behav Res Ther 45, 20192033.
  • Bliss, T.V. & Collingridge, G.L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 3139.
  • Branco, M.R., Ficz, G. & Reik, W. (2012) Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet 13, 713.
  • Bredy, T.W., Wu, H., Crego, C., Zellhoefer, J., Sun, Y.E. & Barad, M. (2007) Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear. Learn Mem 14, 268276.
  • Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. & Baylin, S.B. (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21, 103107.
  • Challen, G.A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J.S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., Liang, S., Lu, Y., Darlington, G.J., Meissner, A., Issa, J.P., Godley, L.A., Li, W. & Goodell, M.A. (2012) Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet 44, 2331.
  • Champagne, F.A. (2008) Epigenetic mechanisms and the transgenerational effects of maternal care. Front Neuroendocrinol 29, 386397.
  • Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R. & Greenberg, M.E. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 302, 885889.
  • Chertkow-Deutsher, Y., Cohen, H., Klein, E. & Ben-Shachar, D. (2010) DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2. Int J Neuropsychopharmacol 13, 347359.
  • Chwang, W.B., O'Riordan, K.J., Levenson, J.M. & Sweatt, J.D. (2006) ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning. Learn Mem 13, 322328.
  • Cipriany, B.R., Murphy, P.J., Hagarman, J.A., Cerf, A., Latulippe, D., Levy, S.L., Benitez, J.J., Tan, C.P., Topolancik, J., Soloway, P.D. & Craighead, H.G. (2012) Real-time analysis and selection of methylated DNA by fluorescence-activated single molecule sorting in a nanofluidic channel. Proc Natl Acad Sci U S A 109, 84778482.
  • Collins, A.L., Levenson, J.M., Vilaythong, A.P., Richman, R., Armstrong, D.L., Noebels, J.L., David, S.J. & Zoghbi, H.Y. (2004) Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet 13, 26792689.
  • Cornelis, M.C., Nugent, N.R., Amstadter, A.B. & Koenen, K.C. (2010) Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies. Curr Psychiatry Rep 12, 313326.
  • Crews, D. (2011) Epigenetic modifications of brain and behavior: theory and practice. Horm Behav 59, 393398.
  • Davis, T. & Vaisvila, R. (2011) High sensitivity 5-hydroxymethylcytosine detection in Balb/C brain tissue. J Vis Exp 48, e2661.
  • Day, J.J. & Sweatt, J.D. (2010) DNA methylation and memory formation. Nat Neurosci 13, 13191323.
  • Dong, E., Guidotti, A., Grayson, D.R. & Costa, E. (2007) Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proc Natl Acad Sci U S A 104, 46764681.
  • Dunn, A.J. (2006) Effects of cytokines and infections on brain neurochemistry. Clin Neurosci Res 6, 5268.
  • Ehrlich, M., Gama-Sosa, M.A., Huang, L.H., Midgett, R.M., Kuo, K.C., McCune, R.A. & Gehrke, C. (1982) Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res 10, 27092721.
  • Ellaway, C. & Christodoulou, J. (2001) Rett syndrome: clinical characteristics and recent genetic advances. Disabil Rehabil 23, 98106.
  • Falkenberg, V.R., Gurbaxani, B.M., Unger, E.R. & Rajeevan, M.S. (2011) Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association. Neuromolecular Med 13, 6676.
  • Feng, J., Zhou, Y., Campbell, S.L., Le, T., Li, E., Sweatt, J.D., Silva, A.J. & Fan, G. (2010) Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nat Neurosci 13, 423430.
  • Flusberg, B.A., Webster, D.R., Lee, J.H., Travers, K.J., Olivares, E.C., Clark, T.A., Korlach, J. & Turner, S.W. (2010) Direct detection of DNA methylation during single-molecule, real-time sequencing. Nat Methods 7, 461465.
  • Fraga, M.F., Ballestar, E., Paz, M.F. et al. (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102, 1060410609.
  • Franklin, T.B., Russig, H., Weiss, I.C., Graff, J., Linder, N., Michalon, A., Vizi, S. & Mansuy, I.M. (2010) Epigenetic transmission of the impact of early stress across generations. Biol Psychiatry 68, 408415.
  • Freeman, J.M., Finkelstein, J.D. & Mudd, S.H. (1975) Folate-responsive homocystinuria and "schizophrenia". A defect in methylation due to deficient 5,10-methylenetetrahydrofolate reductase activity. N Engl J Med 292, 491496.
  • Friedman, M.J. (1997) Posttraumatic stress disorder. J Clin Psychiatry 58 (Suppl. 9), 3336.
  • Fuks, F., Burgers, W.A., Brehm, A., Hughes-Davies, L. & Kouzarides, T. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24, 8891.
  • Gibbs, J.R., van der Brug, M.P., Hernandez, D.G., Traynor, B.J., Nalls, M.A., Lai, S.L., Arepalli, S., Dillman, A., Rafferty, I.P., Troncoso, J., Johnson, R., Zielke, H.R., Ferrucci, L., Longo, D.L., Cookson, M.R. & Singleton, A.B. (2010) Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet 6, e1000952.
  • Graff, J. & Mansuy, I.M. (2009) Epigenetic dysregulation in cognitive disorders. Eur J Neurosci 30, 18.
  • Grafstrom, R.H., Yuan, R. & Hamilton, D.L. (1985) The characteristics of DNA methylation in an in vitro DNA synthesizing system from mouse fibroblasts. Nucleic Acids Res 13, 28272842.
  • Guo, J.U., Su, Y., Zhong, C., Ming, G.L. & Song, H. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423434.
  • Han, K. & Kim, E. (2008) Synaptic adhesion molecules and PSD-95. Prog Neurobiol 84, 263283.
  • Hashimshony, T., Zhang, J., Keshet, I., Bustin, M. & Cedar, H. (2003) The role of DNA methylation in setting up chromatin structure during development. Nat Genet 34, 187192.
  • Heim, C. & Nemeroff, C.B. (2001) The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 49, 10231039.
  • Hirschhorn, J.N. & Daly, M.J. (2005) Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6, 95108.
  • Holsboer, F. (2008) How can we realize the promise of personalized antidepressant medicines? Nat Rev Neurosci 9, 638646.
  • Holscher, C. (1999) Synaptic plasticity and learning and memory: LTP and beyond. J Neurosci Res 58, 6275.
  • Hubler, T.R. & Scammell, J.G. (2004) Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones 9, 243252.
  • Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H. (2013) Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development. Nucleic Acids Res 41, 738745.
  • Illingworth, R.S., Gruenewald-Schneider, U., Webb, S., Kerr, A.R., James, K.D., Turner, D.J., Smith, C., Harrison, D.J., Andrews, R. & Bird, A.P. (2010) Orphan CpG islands identify numerous conserved promoters in the mammalian genome. PLoS Genet 6, e1001134.
  • Inoue, A. & Zhang, Y. (2011) Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science 334, 194.
  • Iqbal, K., Jin, S.G., Pfeifer, G.P. & Szabo, P.E. (2011) Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A 108, 36423647.
  • Issa, J.P. (2000) CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249, 101118.
  • Jaenisch, R. & Bird, A. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33 (Suppl.), 245254.
  • Jin, S.G., Wu, X., Li, A.X. & Pfeifer, G.P. (2011) Genomic mapping of 5-hydroxymethylcytosine in the human brain. Nucleic Acids Res 39, 50155024.
  • Jones, P.A. (1999) The DNA methylation paradox. Trends Genet 15, 3437.
  • Jones, P.A. (2012) Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet 13, 484492.
  • Jones, P.L., Veenstra, G.J., Wade, P.A., Vermaak, D., Kass, S.U., Landsberger, N., Strouboulis, J. & Wolffe, A.P. (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19, 187191.
  • Kagan, B.L., Sultzer, D.L., Rosenlicht, N. & Gerner, R.H. (1990) Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry 147, 591595.
  • Kantarjian, H., Issa, J.P., Rosenfeld, C.S., Bennett, J.M., Albitar, M., DiPersio, J., Klimek, V., Slack, J., de Castro, C., Ravandi, F., Helmer, R. III, Shen, L., Nimer, S.D., Leavitt, R., Raza, A. & Saba, H. (2006) Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 106, 17941803.
  • Kantarjian, H., Oki, Y., Garcia-Manero, G., Huang, X., O'Brien, S., Cortes, J., Faderl, S., Bueso-Ramos, C., Ravandi, F., Estrov, Z., Ferrajoli, A., Wierda, W., Shan, J., Davis, J., Giles, F., Saba, H.I. & Issa, J.P. (2007) Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood 109, 5257.
  • Kantlehner, M., Kirchner, R., Hartmann, P., Ellwart, J.W., Alunni-Fabbroni, M. & Schumacher, A. (2011) A high-throughput DNA methylation analysis of a single cell. Nucleic Acids Res 39, e44.
  • Kass, S.U., Landsberger, N. & Wolffe, A.P. (1997) DNA methylation directs a time-dependent repression of transcription initiation. Curr Biol 7, 157165.
  • Keller, S., Sarchiapone, M., Zarrilli, F. et al. (2010) Increased BDNF promoter methylation in the Wernicke area of suicide subjects. Arch Gen Psychiatry 67, 258267.
  • Kessler, R.C., Berglund, P., Demler, O., Jin, R., Merikangas, K.R. & Walters, E.E. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62, 593602.
  • Kinney, S.M., Chin, H.G., Vaisvila, R., Bitinaite, J., Zheng, Y., Esteve, P.O., Feng, S., Stroud, H., Jacobsen, S.E. & Pradhan, S. (2011) Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes. J Biol Chem 286, 2468524693.
  • Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J.C., Pariante, C.M., Pace, T.W., Mercer, K.B., Mayberg, H.S., Bradley, B., Nemeroff, C.B., Holsboer, F., Heim, C.M., Ressler, K.J., Rein, T. & Binder, E.B. (2013) Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 16, 3341.
  • Ko, M., Huang, Y., Jankowska, A.M., Pape, U.J., Tahiliani, M., Bandukwala, H.S., An, J., Lamperti, E.D., Koh, K.P., Ganetzky, R., Liu, X.S., Aravind, L., Agarwal, S., Maciejewski, J.P. & Rao, A. (2010) Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468, 839843.
  • Kobayashi, H., Sakurai, T., Imai, M., Takahashi, N., Fukuda, A., Yayoi, O., Sato, S., Nakabayashi, K., Hata, K., Sotomaru, Y., Suzuki, Y. & Kono, T. (2012) Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks. PLoS Genet 8, e1002440.
  • Koenen, K.C. (2007) Genetics of posttraumatic stress disorder: review and recommendations for future studies. J Trauma Stress 20, 737750.
  • Koenen, K.C. & Uddin, M. (2010) FKBP5 polymorphisms modify the effects of childhood trauma. Neuropsychopharmacology 35, 16231624.
  • Koenen, K.C., Uddin, M., Chang, S.C., Aiello, A.E., Wildman, D.E., Goldmann, E. & Galea, S. (2011) SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety 28, 639647.
  • Kornblith, A.B., Herndon, J.E., Silverman, L.R., Demakos, E.P., Odchimar-Reissig, R., Holland, J.F., Powell, B.L., DeCastro, C., Ellerton, J., Larson, R.A., Schiffer, C.A. & Holland, J.C. (2002) Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol 20, 24412452.
  • Labonte, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Mechawar, N., Szyf, M., Meaney, M.J. & Turecki, G. (2012) Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 69, 722731.
  • Ladd-Acosta, C., Pevsner, J., Sabunciyan, S., Yolken, R.H., Webster, M.J., Dinkins, T., Callinan, P.A., Fan, J.B., Potash, J.B. & Feinberg, A.P. (2007) DNA methylation signatures within the human brain. Am J Hum Genet 81, 13041315.
  • Laurent, L., Wong, E., Li, G., Huynh, T., Tsirigos, A., Ong, C.T., Low, H.M., Kin Sung, K.W., Rigoutsos, I., Loring, J. & Wei, C.L. (2010) Dynamic changes in the human methylome during differentiation. Genome Res 20, 320331.
  • Leach, P.T., Poplawski, S.G., Kenney, J.W., Hoffman, B., Liebermann, D.A., Abel, T. & Gould, T.J. (2012) Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory. Learn Mem 19, 319324.
  • Lee, R.S., Tamashiro, K.L., Yang, X., Purcell, R.H., Harvey, A., Willour, V.L., Huo, Y., Rongione, M., Wand, G.S. & Potash, J.B. (2010) Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. Endocrinology 151, 43324343.
  • Li, W. & Liu, M. (2011) Distribution of 5-hydroxymethylcytosine in different human tissues. J Nucleic Acids 2011, 870726.
  • Lister, R., Pelizzola, M., Dowen, R.H., Hawkins, R.D., Hon, G., Tonti-Filippini, J., Nery, J.R., Lee, L., Ye, Z., Ngo, Q.M., Edsall, L., Antosiewicz-Bourget, J., Stewart, R., Ruotti, V., Millar, A.H., Thomson, J.A., Ren, B. & Ecker, J.R. (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature 462, 315322.
  • Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P.M. & Meaney, M.J. (1997) Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 277, 16591662.
  • Lock, L.F., Takagi, N. & Martin, G.R. (1987) Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation. Cell 48, 3946.
  • Logue, M.W., Baldwin, C., Guffanti, G., Melista, E., Wolf, E.J., Reardon, A.F., Uddin, M., Wildman, D., Galea, S., Koenen, K.C. & Miller, M.W. (2013) A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol Psychiatry 18, 937942.
  • Ma, D.K., Chiang, C.H., Ponnusamy, K., Ming, G.L. & Song, H. (2008) G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells 26, 21312141.
  • MacMillan, H.L., Fleming, J.E., Streiner, D.L., Lin, E., Boyle, M.H., Jamieson, E., Duku, E.K., Walsh, C.A., Wong, M.Y. & Beardslee, W.R. (2001) Childhood abuse and lifetime psychopathology in a community sample. Am J Psychiatry 158, 18781883.
  • Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G. & Sun, Y.E. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302, 890893.
  • Maunakea, A.K., Nagarajan, R.P., Bilenky, M. et al. (2010) Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature 466, 253257.
  • McGhee, J.D. & Felsenfeld, G. (1980) Nucleosome structure. Annu Rev Biochem 49, 11151156.
  • McGowan, P.O., Sasaki, A., D'Alessio, A.C., Dymov, S., Labonte, B., Szyf, M., Turecki, G. & Meaney, M.J. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12, 342348.
  • Mehta, D. & Binder, E.B. (2012) Gene x environment vulnerability factors for PTSD: the HPA-axis. Neuropharmacology 62, 654662.
  • Meissner, A., Mikkelsen, T.S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B.E., Nusbaum, C., Jaffe, D.B., Gnirke, A., Jaenisch, R. & Lander, E.S. (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766770.
  • Mifsud, K.R., Gutierrez-Mecinas, M., Trollope, A.F., Collins, A., Saunderson, E.A. & Reul, J.M. (2011) Epigenetic mechanisms in stress and adaptation. Brain Behav Immun 25, 13051315.
  • Migaud, M., Charlesworth, P., Dempster, M., Webster, L.C., Watabe, A.M., Makhinson, M., He, Y., Ramsay, M.F., Morris, R.G., Morrison, J.H., O'Dell, T.J. & Grant, S.G. (1998) Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature 396, 433439.
  • Mill, J. & Petronis, A. (2007) Molecular studies of major depressive disorder: the epigenetic perspective. Mol Psychiatry 12, 799814.
  • Miller, C.A. & Sweatt, J.D. (2007) Covalent modification of DNA regulates memory formation. Neuron 53, 857869.
  • Moarefi, A.H. & Chedin, F. (2011) ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation. J Mol Biol 409, 758772.
  • Momparler, R.L. (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin Hematol 42, S9S16.
  • Mullen, P.E., Martin, J.L., Anderson, J.C., Romans, S.E. & Herbison, G.P. (1996) The long-term impact of the physical, emotional, and sexual abuse of children: a community study. Child Abuse Negl 20, 721.
  • Murgatroyd, C., Patchev, A.V., Wu, Y., Micale, V., Bockmuhl, Y., Fischer, D., Holsboer, F., Wotjak, C.T., Almeida, O.F. & Spengler, D. (2009) Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 12, 15591566.
  • Nan, X., Ng, H.H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N. & Bird, A. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386389.
  • Norrholm, S.D., Jovanovic, T., Smith, A.K., Binder, E., Klengel, T., Conneely, K., Mercer, K.B., Davis, J.S., Kerley, K., Winkler, J., Gillespie, C.F., Bradley, B. & Ressler, K.J. (2013) Differential genetic and epigenetic regulation of catechol-O-methyltransferase is associated with impaired fear inhibition in posttraumatic stress disorder. Front Behav Neurosci 7, 30.
  • Ooi, S.K., Qiu, C., Bernstein, E., Li, K., Jia, D., Yang, Z., Erdjument-Bromage, H., Tempst, P., Lin, S.P., Allis, C.D., Cheng, X. & Bestor, T.H. (2007) DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature 448, 714717.
  • Orr, S.P., Metzger, L.J., Lasko, N.B., Macklin, M.L., Peri, T. & Pitman, R.K. (2000) De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol 109, 290298.
  • Pastor, W.A., Pape, U.J., Huang, Y., Henderson, H.R., Lister, R., Ko, M., McLoughlin, E.M., Brudno, Y., Mahapatra, S., Kapranov, P., Tahiliani, M., Daley, G.Q., Liu, X.S., Ecker, J.R., Milos, P.M., Agarwal, S. & Rao, A. (2011) Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature 473, 394397.
  • Penn, N.W., Suwalski, R., O'Riley, C., Bojanowski, K. & Yura, R. (1972) The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. Biochem J 126, 781790.
  • Perilla, J.L., Norris, F.H. & Lavizzo, E.A. (2002) Ethnicity, culture, and disaster response: identifying and explaining ethnic differences in PTSD six months after Hurricane Andrew. J Soc Clin Psychol 21, 2045.
  • Popp, C., Dean, W., Feng, S.H., Cokus, S.J., Andrews, S., Pellegrini, M., Jacobsen, S.E. & Reik, W. (2010) Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 463, 11011105.
  • Radtke, K.M., Ruf, M., Gunter, H.M., Dohrmann, K., Schauer, M., Meyer, A. & Elbert, T. (2011) Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry 1, e21.
  • Ramsahoye, B.H., Biniszkiewicz, D., Lyko, F., Clark, V., Bird, A.P. & Jaenisch, R. (2000) Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A 97, 52375242.
  • Razin, A. (1998) CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J 17, 49054908.
  • Regland, B., Johansson, B.V. & Gottfries, C.G. (1994) Homocysteinemia and schizophrenia as a case of methylation deficiency. J Neural Transm Gen Sect 98, 143152.
  • Reik, W. & Walter, J. (2001) Evolution of imprinting mechanisms: the battle of the sexes begins in the zygote. Nat Genet 27, 255256.
  • Renthal, W., Maze, I., Krishnan, V., Covington, H.E. III, Xiao, G., Kumar, A., Russo, S.J., Graham, A., Tsankova, N., Kippin, T.E., Kerstetter, K.A., Neve, R.L., Haggarty, S.J., McKinsey, T.A., Bassel-Duby, R., Olson, E.N. & Nestler, E.J. (2007) Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 56, 517529.
  • Ressler, K.J., Mercer, K.B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S.D., Kilaru, V., Smith, A.K., Myers, A.J., Ramirez, M., Engel, A., Hammack, S.E., Toufexis, D., Braas, K.M., Binder, E.B. & May, V. (2011) Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 470, 492497.
  • Rideout, W.M. III, Coetzee, G.A., Olumi, A.F. & Jones, P.A. (1990) 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249, 12881290.
  • Risch, N. & Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science 273, 15161517.
  • Roberts, A.L., Gilman, S.E., Breslau, J., Breslau, N. & Koenen, K.C. (2011) Race/ethnic differences in exposure to traumatic events, development of post-traumatic stress disorder, and treatment-seeking for post-traumatic stress disorder in the United States. Psychol Med 41, 7183.
  • Roth, T.L., Zoladz, P.R., Sweatt, J.D. & Diamond, D.M. (2011) Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res 45, 919926.
  • Rudek, M.A., Zhao, M., He, P., Hartke, C., Gilbert, J., Gore, S.D., Carducci, M.A. & Baker, S.D. (2005) Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies. J Clin Oncol 23, 39063911.
  • Rusiecki, J.A., Chen, L., Srikantan, V., Zhang, L., Yan, L., Polin, M.L. & Baccarelli, A. (2012) DNA methylation in repetitive elements and post-traumatic stress disorder: a case-control study of US military service members. Epigenomics 4, 2940.
  • Russo, V.E.A., Martienssen, R.A. & Riggs, A.D. (1996) Epigenetic mechanisms of gene regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
  • Salomon, R. & Kaye, A.M. (1970) Methylation of mouse DNA in vivo: di- and tripyrimidine sequences containing 5-methylcytosine. Biochim Biophys Acta 204, 340351.
  • Sasaki, H. & Matsui, Y. (2008) Epigenetic events in mammalian germ-cell development: reprogramming and beyond. Nat Rev Genet 9, 129140.
  • Segman, R.H., Shefi, N., Goltser-Dubner, T., Friedman, N., Kaminski, N. & Shalev, A.Y. (2005) Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry 10, 500513 425.
  • Shirane, K., Toh, H., Kobayashi, H., Miura, F., Chiba, H., Ito, T., Kono, T. & Sasaki, H. (2013) Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. PLoS Genet 9, e1003439.
  • Silverman, L.R., Demakos, E.P., Peterson, B.L., Kornblith, A.B., Holland, J.C., Odchimar-Reissig, R., Stone, R.M., Nelson, D., Powell, B.L., DeCastro, C.M., Ellerton, J., Larson, R.A., Schiffer, C.A. & Holland, J.F. (2002) Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 20, 24292440.
  • Silverman, M.N., Pearce, B.D., Biron, C.A. & Miller, A.H. (2005) Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection. Viral Immunol 18, 4178.
  • Silverman, L.R., McKenzie, D.R., Peterson, B.L., Holland, J.F., Backstrom, J.T., Beach, C.L. & Larson, R.A. (2006) Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 24, 38953903.
  • Simonini, M.V., Camargo, L.M., Dong, E., Maloku, E., Veldic, M., Costa, E. & Guidotti, A. (2006) The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc Natl Acad Sci U S A 103, 15871592.
  • Sirianni, N., Naidu, S., Pereira, J., Pillotto, R.F. & Hoffman, E.P. (1998) Rett syndrome: confirmation of X-linked dominant inheritance, and localization of the gene to Xq28. Am J Hum Genet 63, 15521558.
  • Skelton, K., Ressler, K.J., Norrholm, S.D., Jovanovic, T. & Bradley-Davino, B. (2012) PTSD and gene variants: new pathways and new thinking. Neuropharmacology 62, 628637.
  • Smith, A.E. & Ford, K.G. (2007) Specific targeting of cytosine methylation to DNA sequences in vivo. Nucleic Acids Res 35, 740754.
  • Smith, A.K., Dimulescu, I., Falkenberg, V.R., Narasimhan, S., Heim, C., Vernon, S.D. & Rajeevan, M.S. (2008) Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology 33, 188197.
  • Smith, A.K., Conneely, K.N., Kilaru, V., Mercer, K.B., Weiss, T.E., Bradley, B., Tang, Y., Gillespie, C.F., Cubells, J.F. & Ressler, K.J. (2011) Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet 156B, 700708.
  • Song, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T., Jin, P. & He, C. (2011) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 29, 6872.
  • Stadler, M.B., Murr, R., Burger, L., Ivanek, R., Lienert, F., Scholer, A., van Nimwegen, E., Wirbelauer, C., Oakeley, E.J., Gaidatzis, D., Tiwari, V.K. & Schubeler, D. (2011) DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature 480, 490495.
  • Stahl, S.M. (2007) Novel therapeutics for schizophrenia: targeting glycine modulation of NMDA glutamate receptors. CNS Spectr 12, 423427.
  • Stahl, S.M. (2010) Fooling mother nature: epigenetics and novel treatments for psychiatric disorders. CNS Spectr 15, 358365.
  • Sternberg, E.M. (2006) Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 6, 318328.
  • Strathdee, G. & Brown, R. (2002) Aberrant DNA methylation in cancer: potential clinical interventions. Expert Rev Mol Med 4, 117.
  • Sultan, F.A., Wang, J., Tront, J., Liebermann, D.A. & Sweatt, J.D. (2012) Genetic deletion of Gadd45b, a regulator of active DNA demethylation, enhances long-term memory and synaptic plasticity. J Neurosci 32, 1705917066.
  • Suzuki, M.M. & Bird, A. (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9, 465476.
  • Szyf, M. (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu Rev Pharmacol Toxicol 49, 243263.
  • Szyf, M., Weaver, I.C., Champagne, F.A., Diorio, J. & Meaney, M.J. (2005) Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Front Neuroendocrinol 26, 139162.
  • Tahiliani, M., Koh, K.P., Shen, Y., Pastor, W.A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L.M., Liu, D.R., Aravind, L. & Rao, A. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930935.
  • Taylor, S.M. & Jones, P.A. (1985) Cellular differentiation. Int J Obes 9 (Suppl. 1), 1521.
  • Tremolizzo, L., Carboni, G., Ruzicka, W.B., Mitchell, C.P., Sugaya, I., Tueting, P., Sharma, R., Grayson, D.R., Costa, E. & Guidotti, A. (2002) An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci U S A 99, 1709517100.
  • Tsankova, N.M., Berton, O., Renthal, W., Kumar, A., Neve, R.L. & Nestler, E.J. (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9, 519525.
  • Turek-Plewa, J. & Jagodzinski, P.P. (2005) The role of mammalian DNA methyltransferases in the regulation of gene expression. Cell Mol Biol Lett 10, 631647.
  • Turner, B.M. (2002) Cellular memory and the histone code. Cell 111, 285291.
  • Uddin, M., Aiello, A.E., Wildman, D.E., Koenen, K.C., Pawelec, G., de Los, S.R., Goldmann, E. & Galea, S. (2010) Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc Natl Acad Sci U S A 107, 94709475.
  • Valinluck, V. & Sowers, L.C. (2007) Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res 67, 946950.
  • Venolia, L. & Gartler, S.M. (1983) Comparison of transformation efficiency of human active and inactive X-chromosomal DNA. Nature 302, 8283.
  • Venter, J.C., Adams, M.D., Myers, E.W. et al. (2001) The sequence of the human genome. Science 291, 13041351.
  • Vermetten, E. & Bremner, J.D. (2002) Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder. Depress Anxiety 16, 1438.
  • Weaver, I.C., Szyf, M. & Meaney, M.J. (2002) From maternal care to gene expression: DNA methylation and the maternal programming of stress responses. Endocr Res 28, 699.
  • Weaver, I.C., Cervoni, N., Champagne, F.A., D'Alessio, A.C., Sharma, S., Seckl, J.R., Dymov, S., Szyf, M. & Meaney, M.J. (2004) Epigenetic programming by maternal behavior. Nat Neurosci 7, 847854.
  • Weaver, I.C., Champagne, F.A., Brown, S.E., Dymov, S., Sharma, S., Meaney, M.J. & Szyf, M. (2005) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci 25, 1104511054.
  • Weaver, I.C., Meaney, M.J. & Szyf, M. (2006) Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood. Proc Natl Acad Sci U S A 103, 34803485.
  • Weiss, E.L., Longhurst, J.G. & Mazure, C.M. (1999) Childhood sexual abuse as a risk factor for depression in women: psychosocial and neurobiological correlates. Am J Psychiatry 156, 816828.
  • Wolf, S.F., Jolly, D.J., Lunnen, K.D., Friedmann, T. & Migeon, B.R. (1984) Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci U S A 81, 28062810.
  • Wong, C.M. (2002) Post-traumatic stress disorder: advances in psychoneuroimmunology. Psychiatr Clin North Am 25, 369383 vii.
  • Xie, S., Wang, Z., Okano, M., Nogami, M., Li, Y., He, W.W., Okumura, K. & Li, E. (1999) Cloning, expression and chromosome locations of the human DNMT3 gene family. Gene 236, 8795.
  • Xie, W., Barr, C.L., Kim, A., Yue, F., Lee, A.Y., Eubanks, J., Dempster, E.L. & Ren, B. (2012) Base-resolution analyses of sequence and parent-of-origin dependent DNA methylation in the mouse genome. Cell 148, 816831.
  • Xie, P., Kranzler, H.R., Yang, C., Zhao, H., Farrer, L.A. & Gelernter, J. (2013) Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. Biol Psychiatry 74, 656663.
  • Yang, X., Ewald, E.R., Huo, Y., Tamashiro, K.L., Salvatori, R., Sawa, A., Wand, G.S. & Lee, R.S. (2012) Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochem Biophys Res Commun 420, 570575.
  • Yehuda, R. & Bierer, L.M. (2009) The relevance of epigenetics to PTSD: implications for the DSM-V. J Trauma Stress 22, 427434.
  • Yehuda, R. & LeDoux, J. (2007) Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron 56, 1932.
  • Yehuda, R., Flory, J.D., Pratchett, L.C., Buxbaum, J., Ising, M. & Holsboer, F. (2010) Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD. Psychopharmacology (Berl) 212, 405417.
  • Yoder, J.A., Walsh, C.P. & Bestor, T.H. (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13, 335340.
  • Zhang, Y., Ng, H.H., Erdjument-Bromage, H., Tempst, P., Bird, A. & Reinberg, D. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev 13, 19241935.
  • Zieker, J., Zieker, D., Jatzko, A., Dietzsch, J., Nieselt, K., Schmitt, A., Bertsch, T., Fassbender, K., Spanagel, R., Northoff, H. & Gebicke-Haerter, P.J. (2007) Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder. Mol Psychiatry 12, 116118.