gbb12142-sup-0001-FigureS1.tiffTIFF image1521KFigure S1. Electroencephalography recordings from the two test mice for (a) SM/J, (b) DBA/1J and (c) DBA/2J inbred strains illustrating how the burst frequencies were determined. Around 9–10 Hz SWDs are observed in both SM/J mice compared to the 6–8 Hz SWDs in the closely related DBA strains. The arrow indicates the onset of the SWD episode.
gbb12142-sup-0002-FigureS2.tiffTIFF image1521KFigure S2. Temporal clustering of SWD in SWD+ strains. Distribution of inter-SWD intervals in minutes (x-axis) against the respective β quantile (y-axis) for two previously known SWD strains (a) and for the five new SWD+ strains (b) taken from 24-h EEG data. The straight red line in each plot shows the expected distribution fit if SWD were randomly spaced, and 95% confidence limits shown as dashed lines. A significant number of SWD intervals were much shorter than expected (density of black dots to the left of the red line), indicating clustering.
gbb12142-sup-0003-FigureS3.tiffTIFF image1521KFigure S3. Pairwise SNP identity between SWD+ and SWD– mouse strains. Shown is a matrix of SNP identity between strains used in this study, from SNP genetic variation query tools at the Mouse Phenome Database ( using a combination of Sanger Centre and Center for Genome Dynamics imputed SNPs. Strains were grouped by SWD+ (red shading) or SWD– (blue shading), and sorted by decreasing identity within each group. At the right, the results of Student's t-test are shown, comparing % identities for a test strain with each group – statistically significant or suggestive P-values are shaded in red.
gbb12142-sup-0004-FigureS4.tiffTIFF image1521KFigure S4. Haplotype association mapping of SWD in 27 inbred strains. The EMMA algorithm was used to examine association between SWD traits (SWD binary – positive or negative for SWD; SWD length; SWD incidence) and 233554 SNPs from the EMMA correction server (
gbb12142-sup-0005-FigureS5.tiffTIFF image1521KFigure S5. Inferred alleles for the top four chromosomal locations containing peak SNPs. Shown is a chart of inferred SWD susceptibility alleles recoded to reference their origin as being from SWD+ strain ‘S’ (susceptible – red shading), or SWD– strain ‘R’ (resistant – blue shading). Blank green shaded cells reflect either alternate or indeterminate allele for that respective marker. The SWD phenotypes are shown on the right.

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