Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4 (pages 928–941)
E. Ey, M. Yang, A. M. Katz, L. Woldeyohannes, J. L. Silverman, C. S. Leblond, P. Faure, N. Torquet, A.-M. Le Sourd, T. Bourgeron and J. N. Crawley
Article first published online: 10 OCT 2012 | DOI: 10.1111/j.1601-183X.2012.00849.x
Our findings indicate an absence of autism-relevant behavioral phenotypes in later generations of Nlgn4 mice tested at two locations. Testing environment and methods differed from the original study in some aspects, although the presence of normal sociability was seen in all genotypes when methods taken from Jamain et al. (2008) were used. The divergent results obtained in the present studies indicate that phenotypes may not be replicable across breeding generations, and highlight the significant roles of environmental, generational and/or procedural factors on behavioral phenotypes.
Vol. 12, Issue 7, 748, Article first published online: 1 OCT 2013