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Genes, Brain and Behavior

Cover image for Vol. 12 Issue 1

February 2013

Volume 12, Issue 1

Pages 1–145, i–i

  1. Review

    1. Top of page
    2. Review
    3. Original Articles
    4. IBANGS
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      Genes, behavior and next-generation RNA sequencing (pages 1–12)

      R. Hitzemann, D. Bottomly, P. Darakjian, N. Walter, O. Iancu, R. Searles, B. Wilmot and S. McWeeney

      Version of Record online: 28 DEC 2012 | DOI: 10.1111/gbb.12007

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      The article reviews recent progress in RNA-Seq analysis and emphasizes applications of this technology in a brain-behavior context. Issues associated with experimental design, data normalization and data analysis are empasized. RNA-Seq embraces the complexity of the transcriptome and provides a mechanism to understand the underlying regulatory code; the potential to inform the brain-behavior relationship is substantial.

  2. Original Articles

    1. Top of page
    2. Review
    3. Original Articles
    4. IBANGS
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      Does COMT genotype influence the effects of d-amphetamine on executive functioning? (pages 13–20)

      M. C. Wardle, A. B. Hart, A. A. Palmer and H. de Wit

      Version of Record online: 29 DEC 2012 | DOI: 10.1111/gbb.12012

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      Failure to replicate Mattay et al. (2003). COMT did not moderate effects of amphetamine on executive functioning (WCST perseverative errors).

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      Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome (pages 21–33)

      J. E. Eipper-Mains, D. D. Kiraly, M. O. Duff, M. J. Horowitz, C. J. McManus, B. A. Eipper, B. R. Graveley and R. E. Mains

      Version of Record online: 27 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00873.x

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      Genes labeled yellow showed a sustained increase in Coc and W/D, red genes increased in W/D only and blue genes had decreased expression in both Coc and W/D.

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      Cocaine produces conditioned place aversion in mice with a cocaine-insensitive dopamine transporter (pages 34–38)

      B. O'Neill, M. R. Tilley and H. H. Gu

      Version of Record online: 22 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00872.x

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      Cocaine produces conditioned place aversion in knock-in mice with a cocaine insensitive dopamine transporter.

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      Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence (pages 39–46)

      N. Fernàndez-Castillo, C. Roncero, L. Grau-Lopez, C. Barral, G. Prat, L. Rodriguez-Cintas, C. Sánchez-Mora, M. Gratacòs, J.A. Ramos-Quiroga, M. Casas, M. Ribasés and B. Cormand

      Version of Record online: 10 JAN 2013 | DOI: 10.1111/gbb.12013

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      A case–control association study of 37 candidate genes reveals involvement of HTR2A in cocaine dependence.

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      An assessment of gene-by-environment interactions in developmental dyslexia-related phenotypes (pages 47–55)

      S. Mascheretti, A. Bureau, M. Battaglia, D. Simone, E. Quadrelli, J. Croteau, M. R. Cellino, R. Giorda, S. Beri, M. Maziade and C. Marino

      Version of Record online: 24 NOV 2012 | DOI: 10.1111/gbb.12000

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      In the present study, we investigated the presence of GxE effects for the DYX1C1, DCDC2, KIAA0319 and ROBO1 genes, and for 7 specified environmental moderators in 165 nuclear families in which at least one member had DD, by implementing a general test for GxE interaction in sib pair-based association analysis of quantitative traits. Our results support a diathesis-stress model for both reading and memory composites: GxE effects were found between some specified environmental moderators (i.e., maternal smoke during pregnancy, birth weight, and socio-economic status) and both the allelic variants of the DYX1C1-1259C/G marker.

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      Dense-map genome scan for dyslexia supports loci at 4q13, 16p12, 17q22; suggests novel locus at 7q36 (pages 56–69)

      L. L. Field, K. Shumansky, J. Ryan, D. Truong, E. Swiergala and B. J. Kaplan

      Version of Record online: 7 DEC 2012 | DOI: 10.1111/gbb.12003

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      Family analysis using SNP arrays shows dyslexia linkage peak at 17q22 in MSI2 gene involved in proliferation of neuronal stem cell lineages.

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      Genotype modulates age-related alterations in sensitivity to the aversive effects of ethanol: an eight inbred strain analysis of conditioned taste aversion (pages 70–77)

      E. M. Moore, R. D. Forrest IV and S. L. Boehm II

      Version of Record online: 13 DEC 2012 | DOI: 10.1111/gbb.12004

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      Ethanol induced CTA response varied as a function of age, strain and ethanol dose.

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      Selection for high alcohol preference drinking in mice results in heightened sensitivity and rapid development of acute functional tolerance to alcohol's ataxic effects (pages 78–86)

      B. M. Fritz, N. J. Grahame and S. L. Boehm II

      Version of Record online: 31 AUG 2012 | DOI: 10.1111/j.1601-183X.2012.00830.x

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      Selectively-bred high alcohol-preferring mice are significantly more sensitive to alcohol's ataxic effects and develop more rapid acute functional tolerance than low alcohol-preferring mice.

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      Taok2 controls behavioral response to ethanol in mice (pages 87–97)

      D. Kapfhamer, S. Taylor, M. E. Zou, J. P. Lim, V. Kharazia and U. Heberlein

      Version of Record online: 31 AUG 2012 | DOI: 10.1111/j.1601-183X.2012.00834.x

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      Nervous system-specific loss of Taok2 in mice alters ethanol-induced sedation and consumption.

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      Brain-derived neurotrophic factor genotype is associated with brain gray and white matter tissue volumes recovery in abstinent alcohol-dependent individuals (pages 98–107)

      A. Mon, T. C. Durazzo, S. Gazdzinski, K. E. Hutchison, D. Pennington and D. J. Meyerhoff

      Version of Record online: 11 OCT 2012 | DOI: 10.1111/j.1601-183X.2012.00854.x

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      BDNF Val66Met polymorphism modulates brain lobar gray and white matter volume recovery in short-term alcohol-dependent individuals (Frontal gray and white matter longitudinal volume changes in Val homozygotes and Val/Met heterozygotes between TP1 and TP2)

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      Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease (pages 108–124)

      P. Samadi, A. Boutet, V. V. Rymar, K. Rawal, J. Maheux, J.-C. Kvann, M. Tomaszewski, F. Beaubien, J. F. Cloutier, D. Levesque and A. F. Sadikot

      Version of Record online: 21 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00858.x

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      A relationship exists between BDNF expression in striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.

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      Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients (pages 125–132)

      T. M. Murphy, N. Mullins, M. Ryan, T. Foster, C. Kelly, R. McClelland, J. O'Grady, E. Corcoran, J. Brady, M. Reilly, A. Jeffers, K. Brown, A. Maher, N. Bannan, A. Casement, D. Lynch, S. Bolger, A. Buckley, L. Quinlivan, L. Daly, C. Kelleher and K. M. Malone

      Version of Record online: 26 OCT 2012 | DOI: 10.1111/j.1601-183X.2012.00865.x

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      Increased global DNA methylation is associated with suicide attempts in psychiatric patients.

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      The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients (pages 133–139)

      H. Gu, C. Liu, C. Liu, M. Chen, Q. Zhang, J. Zhai, K. Wang, F. Ji, Z. Xu, Q. Shen, X. Bao, X. Chen, J. Li, Q. Dong and C. Chen

      Version of Record online: 22 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00866.x

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      Increased global DNA methylation is associated with suicide attempts in psychiatric patients.

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      MAOA genotype, social exclusion and aggression: an experimental test of a gene–environment interaction (pages 140–145)

      D. Gallardo-Pujol, A. Andrés-Pueyo and A. Maydeu-Olivares

      Version of Record online: 28 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00868.x

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      Our results support the notion that G×E interactions can be successfully reproduced within a laboratory using analogs and an appropriate design.

  3. IBANGS

    1. Top of page
    2. Review
    3. Original Articles
    4. IBANGS
    1. You have free access to this content

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