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Genes, Brain and Behavior

Cover image for Vol. 12 Issue 2

March 2013

Volume 12, Issue 2

Pages 147–288, i–i

  1. Original Articles

    1. Top of page
    2. Original Articles
    3. Book Review
    4. IBANGS
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      A hierarchical coherent-gene-group model for brain development (pages 147–165)

      I. F. Tsigelny, V. L. Kouznetsova, M. Baitaluk and J.-P. Changeux

      Version of Record online: 28 DEC 2012 | DOI: 10.1111/gbb.12005

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      Tsallis entropy, neurons development and selected gene expression. Evolution of reversed Tsallis entropy (green triangles) during rat brain development (blue and red). Tsallis entropy is the informational entropy reflecting the internal relation of gene groups at any given day of development and represents the measure of disorder. Reversed entropy is opposite to disorder and represents level of structural and functional organization. High levels of entropy correspond to more versatility of the CGGs expression and lower levels correspond to higher organization of the entire system, the number of neurons (blue), and the number of Golgi-stained cortical neurons with full dendritic arborization (red) follow correlated developmental curves indicating a relationship between calculated entropy and gene-controlled neurons and synapses development events.

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      Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes (pages 166–180)

      J. T. Wolstenholme, E. F. Rissman and S. Bekiranov

      Version of Record online: 10 JAN 2013 | DOI: 10.1111/gbb.12010

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      We find an interaction between gonadal development and sex chromosome number that could elucidate the role of chr X and Y genes in behavior.

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      Sensation-seeking genes and physical activity in youth (pages 181–188)

      A. V. Wilkinson, K. P. Gabriel, J. Wang, M. L. Bondy, Q. Dong, X. Wu, S. Shete and M. R. Spitz

      Version of Record online: 24 DEC 2012 | DOI: 10.1111/gbb.12006

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      Being male, reporting higher levels of thrill and adventure seeking and subjective social status, as well as the minor alleles of the SNPs we identified in tryptophan hydroxylase 2 gene and angiotensin I-converting enzyme gene were associated with increased likelihood of meeting PA recommendations, whereas the minor alleles of the SNPs we identified in synaptosomal-associated protein 25 gene and in the cannabinoid receptor 1 gene were associated with decreased likelihood of meeting PA recommendations.

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      Impaired cognitive function and reduced anxiety-related behavior in a promyelocytic leukemia (PML) tumor suppressor protein-deficient mouse (pages 189–202)

      K. Butler, L. A. Martinez and M. V. Tejada-Simon

      Version of Record online: 18 JAN 2013 | DOI: 10.1111/gbb.12014

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      In the mouse brain, PML might have an important role in memory and anxiety. Figure 2 (a) Exploratory behavior and trajectory followed by Pml+/+ control (WT) and Pml–/– (PML KO) mice in the open field task.

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      Neuropsychological effects of the CSMD1 genome-wide associated schizophrenia risk variant rs10503253 (pages 203–209)

      G. Donohoe, J. Walters, A. Hargreaves, E.J. Rose, D.W. Morris, C. Fahey, S. Bellini, E. Cummins, I. Giegling, A.M. Hartmann, H.-J. Möller, P. Muglia, M.J. Owen, M. Gill, M.C. O'Donovan, D. Tropea, D. Rujescu and A. Corvin

      Version of Record online: 22 FEB 2013 | DOI: 10.1111/gbb.12016

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      The CSMD1 variant rs10503253, a genome-wide supported schizophrenia risk variant, is associated with subtle deficits on a range of neuropsychological measures in patients with schizophrenia and controls.

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      Genetic dissection of memory for associative and non-associative learning in Caenorhabditis elegans (pages 210–223)

      H. L. Lau, T. A. Timbers, R. Mahmoud and C. H. Rankin

      Version of Record online: 1 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00863.x

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      A genetic dissection of short- and long-term memory for associative and non-associative learning in C. elegans

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      A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism (pages 224–233)

      A. Dhanushkodi, E. O. Akano, E. E. Roguski, Y. Xue, S. K. Rao, S. G. Matta, T. S. Rex and M. P. McDonald

      Version of Record online: 28 NOV 2012 | DOI: 10.1111/gbb.12001

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      A single injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced dopaminergic cell death.

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      Novel PRRT2 mutations in paroxysmal dyskinesia patients with variant inheritance and phenotypes (pages 234–240)

      X.-R. Liu, M. Wu, N. He, H. Meng, L. Wen, J.-L. Wang, M.-P. Zhang, W.-B. Li, X. Mao, J.-M. Qin, B.-M. Li, B. Tang, Y.-H. Deng, Y.-W. Shi, T. Su, Y.-H. Yi, B.-S. Tang and W.-P. Liao

      Version of Record online: 21 DEC 2012 | DOI: 10.1111/gbb.12008

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      Seven PRRT2 mutations (including five novel mutations) in 15 cases (or families) with paroxysmal dyskinesias (PDs) and PDs-related phenotypes were detected, which extended the spectrum of PRRT2 mutations and provided the evidence that PRRT2 was the causative gene in most familial PDs. The heterogeneity in inheritance patterns of PRRT2 mutations, including autosomal recessive inheritance with compound heterozygous PRRT2 mutations, was identified. Variant phenotypes associated with PRRT2 mutations and EEG abnormalities were reported, including infantile non-convulsion seizures and nocturnal convulsions that were not reported previously

      Ethanol induced CTA response varied as a function of age, strain and ethanol dose.

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      Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice (pages 241–249)

      L. E. Vollmer, S. Ghosal, J. A. Rush, F. R. Sallee, J. P. Herman, M. Weinert and R. Sah

      Version of Record online: 27 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00867.x

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      The glucocorticoid induced receptor regulates spatial learning, reward and behavioral consequences of stress exposure.

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      SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans (pages 250–262)

      C. Jee, J. Lee, J. P. Lim, D. Parry, R. O. Messing and S. L. McIntire

      Version of Record online: 4 SEP 2012 | DOI: 10.1111/j.1601-183X.2012.00829.x

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      We develop a new genetic tool of persistent activation of stress system that demonstrates a novel conserved role of corticotropin-releasing factor (CRF) system.

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      Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice (pages 263–274)

      T. M. Darlington, M. A. Ehringer, C. Larson, T. L. Phang and R. A. Radcliffe

      Version of Record online: 22 FEB 2013 | DOI: 10.1111/gbb.12018

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      RNA-Seq of striatal/whole brain transcriptomes of ILS and ISS mice show differences in numerous biological pathways.

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      Brain gene expression differences are associated with abnormal tail biting behavior in pigs (pages 275–281)

      E. Brunberg, P. Jensen, A. Isaksson and L. J. Keeling

      Version of Record online: 7 DEC 2012 | DOI: 10.1111/gbb.12002

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      Brain gene expression differences are associated with abnormal tail biting behavior in pigs.

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      Allele-specific transcriptional activity of the variable number of tandem repeats in 5′ region of the DRD4 gene is stimulus specific in human neuronal cells (pages 282–287)

      U. M. Paredes, J. P. Quinn and U. M. D'Souza

      Version of Record online: 7 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00857.x

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      The DRD4 5′ VNTR variants exhibit stimulus-specific transcriptional activity in human neuronal cell types.

  2. Book Review

    1. Top of page
    2. Original Articles
    3. Book Review
    4. IBANGS
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      Mouse behavioral testing. How to use mice in behavioral research - by Douglas Wahlsten (page 288)

      Wim E. Crusio

      Version of Record online: 21 NOV 2012 | DOI: 10.1111/j.1601-183X.2012.00864.x

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      Cover of Mouse Behavioral Testing by Douglas Wahlsten

  3. IBANGS

    1. Top of page
    2. Original Articles
    3. Book Review
    4. IBANGS
    1. You have free access to this content

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