Genes, Brain and Behavior

Cover image for Vol. 12 Issue 4

June 2013

Volume 12, Issue 4

Pages 361–477

  1. Original Articles

    1. Top of page
    2. Original Articles
    1. The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G × E effects (pages 361–369)

      L. A. Ray, M. Sehl, S. Bujarski, K. Hutchison, S. Blaine and M.-A. Enoch

      Article first published online: 4 APR 2013 | DOI: 10.1111/gbb.12032

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      This study extends the literature on the interplay between CRHR1 variation and alcoholism, in the context of exposure to traumatic stress. These findings are consistent with the hypothesized role of the extra hypothalamic CRF system dysregulation in the initiation and maintenance of alcoholism.

    2. Sex differences in the effects of chronic stress and food restriction on body weight gain and brain expression of CRF and relaxin-3 in rats (pages 370–387)

      C. Lenglos, A. Mitra, G. Guèvremont and E. Timofeeva

      Article first published online: 12 MAR 2013 | DOI: 10.1111/gbb.12028

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      Repeated stress and food restriction decreased (RCEm-S) and increased (RCEf-S) body weight gain of male and female rats, respectively.

    3. Evidence for interplay between genes and maternal stress in utero: monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5 weeks (pages 388–396)

      J. Hill, G. Breen, J. Quinn, F. Tibu, H. Sharp and A. Pickles

      Article first published online: 7 MAY 2013 | DOI: 10.1111/gbb.12033

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      MAOA-LPR activity status interacts with life events in pregnancy (G × E) to predict infant negative emotionality.

    4. Dopamine receptor D2 deficiency reduces mouse pup ultrasonic vocalizations and maternal responsiveness (pages 397–404)

      T. Curry, P. Egeto, H. Wang, A. Podnos, D. Wasserman and J. Yeomans

      Article first published online: 15 APR 2013 | DOI: 10.1111/gbb.12037

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      Drd2 knockout dams showed elevated prolactin, and disrupted prolactin and retrieval responses to ultrasonic vocalization emitting pups.

    5. The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene (pages 405–413)

      R. E. Sorge, M. L. LaCroix-Fralish, A. H. Tuttle, A. Khoutorsky, S. G. Sotocinal, J.-S. Austin, K. Melmed, S. Labialle, J. V. Schmidt, J. N. Wood, A. K. Naumova and J. S. Mogil

      Article first published online: 19 MAR 2013 | DOI: 10.1111/gbb.12030

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      Decreased formalin-induced licking behavior in mice with a dorsal root ganglion-specific knockout of the gene for the Yin Yang 1 transcription factor.

    6. Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice (pages 414–423)

      E. Azzopardi, M. Typlt, B. Jenkins and S. Schmid

      Article first published online: 10 APR 2013 | DOI: 10.1111/gbb.12038

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      Commercially available knockout (KO) mouse for the α7-nicotinic receptor was used to evaluate its role in sensory filtering [habituation and prepulse inhibition (PPI) of startle, and habituation in the locomotor box], nicotine-enhanced sensorimotor gating and in spatial learning. Mice showed normal habituation. In contrast to previous reports, a mild but very consistent impairment of PPI was observed in these mice. Most importantly, nicotine-enhanced PPI was absent in KO animals, suggesting a crucial role of the α7-nicotinic receptor in enhancing PPI by nicotine. Spatial learning was unperturbed in these animals; however, we found some evidence for a slightly increased anxiety level.

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      High-precision genetic mapping of behavioral traits in the diversity outbred mouse population (pages 424–437)

      R. W. Logan, R. F. Robledo, J. M. Recla, V. M. Philip, J. A. Bubier, J. J. Jay, C. Harwood, T. Wilcox, D. M. Gatti, C. J. Bult, G. A. Churchill and E. J. Chesler

      Article first published online: 20 MAR 2013 | DOI: 10.1111/gbb.12029

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      With fewer than 300 Diversity Outbred mice, QTL can be mapped with 2 Mb precision for many behaviors. Narrowing QTL support interval using phylogeny and sequencing information based on allele effect estimates.

    8. On the genetic basis of face cognition and its relation to fluid cognitive abilities (pages 438–445)

      A. Kiy, O. Wilhelm, A. Hildebrandt, M. Reuter and W. Sommer

      Article first published online: 15 APR 2013 | DOI: 10.1111/gbb.12034

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      The OXTR association with face cognition was opposed for female and male and was completely explained by fluid cognition.

    9. Genetic and environmental contributions to the expression of handedness in chimpanzees (Pan troglodytes) (pages 446–452)

      W. D. Hopkins, M. J. Adams and A. Weiss

      Article first published online: 3 JUN 2013 | DOI: 10.1111/gbb.12044

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      Chimpanzees show population-level handedness for two of three handedness measures. Both direction and strength of handedness are significantly heritable for each measure.

    10. Human alpha- and beta-NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin-deficient mutants (pages 453–464)

      F. Calahorro and M. Ruiz-Rubio

      Article first published online: 20 MAY 2013 | DOI: 10.1111/gbb.12046

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      Abnormal exploratory behavior of Caenorhabditis elegans nrx-1-deficient mutants was rescued expressing either human alpha- or beta-NRXN1 isoforms.

    11. You have free access to this content
      Mice lacking the Parkinson's related GPR37/PAEL receptor show non-motor behavioral phenotypes: age and gender effect (pages 465–477)

      S. Mandillo, E. Golini, D. Marazziti, C. Di Pietro, R. Matteoni and G. P. Tocchini-Valentini

      Article first published online: 6 MAY 2013 | DOI: 10.1111/gbb.12041

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      Anxiety and depression phenotypes in aged GPR37 KO female mice: relevance for the study of PD non-motor symptoms.