Extinction of an instrumental response: a cognitive behavioral assay in Fmr1 knockout mice (pages 451–458)
M. S. Sidorov, D. D. Krueger, M. Taylor, E. Gisin, E. K. Osterweil and M. F. Bear
Version of Record online: 30 APR 2014 | DOI: 10.1111/gbb.12137
Instrumental extinction is exaggerated in Fmr1 KO mice. (a) Schematic shows a test with one acquisition phase, followed by 5 days of extinction. (b) Days to acquisition and (c) performance during acquisition are normal in Fmr1 KO mice. (d) Extinction of correct responding is significantly exaggerated in Fmr1 KO mice (***P = 0.001, repeated measures two-way anova) and post hoc tests show significant exaggeration at days 1–4 (*P < 0.05). (e) Normalization shows significantly exaggerated extinction in Fmr1 KO mice (***P = 0.001), and post hoc tests show a significant exaggeration at day 1 (**P < 0.01). There is no effect of Fmr1 genotype on incorrect responses (f,g) or on the rate of correct responses (h,i).