Association between low renal function and tooth loss over 5 years

Authors

  • Akihiro Yoshihara,

    Corresponding author
    1. Department of Oral Health and Welfare, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
    • Correspondence to:

      Akihiro yoshihara

      Department of Oral Health and Welfare, Division of Oral Science for Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho-Dori, Niigata, 952-8514, Japan.

      Tel: +81 25 227 0906.

      Fax: +81 25 227 0906.

      E-mail: akihiro@dent.niigata-u.ac.jp

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  • Masanori Iwasaki,

    1. Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Hideo Miyazaki,

    1. Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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  • Kazutoshi Nakamura

    1. Department of Community Preventive Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
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Abstract

Objectives

This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.

Material and methods

Subjects comprised 406 female subjects (55–74 years old) who agreed to participate in a baseline examination and a follow-up examination after 5 years. Serum cystatin C levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin C levels over 5 years. Tooth loss over 5 years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin C levels over 5 years.

Results

Results of multiple logistic regression analysis showed that cystatin C change over 5 years, age, number of remaining teeth at baseline, number of sites with ≥4 mm clinical attachment level at baseline and serum 25-hydroxyvitamin D levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin C change over 5 years was 7.70 (= 0.029).

Conclusion

This study indicates a relationship between serum cystatin C levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.

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