Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial

Authors

  • Gerardo Gómez-Moreno,

    Corresponding author
    1. Department of Special Care and Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada, Spain
    • Correspondence to:

      Prof. Gerardo Gómez-Moreno, Facultad de Odontología. Campus Universitario de Cartuja, Colegio Máximo s/n. E-18071 Granada. Spain.

      Tel.: +34 958244085

      Fax: +34 958240908

      E-mail: ggomez@ugr.es

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  • Maribel Cabrera-Ayala,

    1. Department of Special Care and Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada, Spain
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  • Antonio Aguilar-Salvatierra,

    1. Department of Special Care and Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada, Spain
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  • Javier Guardia,

    1. Department of Special Care and Pharmacological Research in Dentistry, Faculty of Dentistry, University of Granada, Granada, Spain
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  • María Piedad Ramírez-Fernández,

    1. Department of Implant Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain
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  • Maximino González-Jaranay,

    1. Department of Periodontics, Faculty of Dentistry, University of Granada, Granada, Spain
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  • José Luis Calvo-Guirado

    1. Department of Implant Dentistry, Faculty of Medicine and Dentistry, University of Murcia, Murcia, Spain
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Abstract

Objective

The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia.

Material and methods

This research took the form of a double-blind, randomized clinical trial. Forty-one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first ‘intervention group’ (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second ‘control group’ (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. The Xerostomia Inventory (XI) was used to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after spray application, were measured.

Results

XI scores decreased significantly (clinically meaningful) from 36.4 ± 7.3 points to 29.1 ± 7.1 (< 0.05) with an XI difference of 7.2 ± 6.1, after the combination among 1% malic acid with xylitol and fluoride application. After 2 weeks of 1% malic acid application, unstimulated and stimulated salivary flows rates increased significantly (< 0.05).

Conclusion

A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates.

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