Type 2 diabetes is associated with low muscle mass in older adults
Article first published online: 23 JAN 2014
© 2014 Japan Geriatrics Society
Geriatrics & Gerontology International
Special Issue: Sarcopenia in Asia. This supplement was published with the support of National Center for Geriatrics and Gerontology.
Volume 14, Issue Supplement S1, pages 115–121, February 2014
How to Cite
Kim, K.-S., Park, K.-S., Kim, M.-J., Kim, S.-K., Cho, Y.-W. and Park, S. W. (2014), Type 2 diabetes is associated with low muscle mass in older adults. Geriatrics & Gerontology International, 14: 115–121. doi: 10.1111/ggi.12189
- Issue published online: 23 JAN 2014
- Article first published online: 23 JAN 2014
- Manuscript Accepted: 1 OCT 2013
- elderly diabetes;
- type 2 diabetes
Our aim was to clarify the association between type 2 diabetes and the risk of low muscle mass in older adults.
In the present study, 414 adults aged 65 years or older (144 patients with type 2 diabetes and 270 control participants) were included. Body composition was measured by dual-energy X-ray absorptiometry. Low muscle mass was defined as the appendicular skeletal muscle mass/height2 (ASM/Ht2) or appendicular skeletal muscle mass/weight (ASM/Wt) of <2 SD below the sex-specific normal mean of the young reference group, or <lower 20th percentile of total body skeletal muscle mass/weight (TSM/Wt) from control participants.
Older men with type 2 diabetes showed significantly lower appendicular skeletal muscle mass than those without diabetes (19.5 ± 3.5 kg vs 21.0 ± 2.8 kg, P < 0.001). The prevalence of low muscle mass was consistently higher in older men with diabetes than those without diabetes defined by ASM/Ht2 (57.6% vs 41.5%, P = 0.040), ASM/Wt (23.7% vs 12.3%, P = 0.046) and TSM/Wt (49.2% vs 20.0%, P < 0.001). In older women with diabetes, the prevalence of low muscle mass was higher than those without diabetes by ASM/Wt (25.9% vs 15.0%, P = 0.044) and TSM/Wt (32.9% vs 20.0%, P = 0.030), but not by ASM/Ht2 (7.1% vs 8.6%, P = 0.685). The risk of low muscle mass was approximately two- to fourfold higher in older adults with type 2 diabetes, even after adjusting for age, body mass index, current smoking and other risk factors.
In Korean older adults, type 2 diabetes is associated with low muscle mass. Geriatr Gerontol Int 2014; 14 (Suppl. 1): 115–121.