Conflict of Interest: The authors report no conflict of interest.
Angiotensin I-Converting Enzyme Gene (I/D) Polymorphism in Patients With Migraine
Version of Record online: 26 DEC 2012
© 2012 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 53, Issue 1, pages 161–164, January 2013
How to Cite
Horasanlı, B., Ataç, F. B., Çöven, İ., Karakurum Goksel, B. and Benli, S. (2013), Angiotensin I-Converting Enzyme Gene (I/D) Polymorphism in Patients With Migraine. Headache: The Journal of Head and Face Pain, 53: 161–164. doi: 10.1111/head.12008
- Issue online: 8 JAN 2013
- Version of Record online: 26 DEC 2012
- Manuscript Accepted: 8 OCT 2012
- migraine with aura;
- angiotensin I-converting enzyme gene (I/D) polymorphism
In addition to the wide expression in many tissues including vascular endothelial cells, production of angiotensin II and degradation of bradykinin may indicate that angiotensin-converting enzyme could be involved in vascular tension and blood pressure. It has been reported that the deletion allele of the angiotensin-converting enzyme gene is associated with increased serum angiotensin-converting enzyme levels and linked to cerebrovascular diseases. In this study, the possible association of migraine with aura with the angiotensin-converting enzyme deletion–deletion (DD) and the angiotensin–converting enzyme insertion–deletion (ID) genotype was investigated in Turkish patients. To investigate the role of the angiotensin-converting enzyme I/D polymorphism in Turkish patients with migraine with aura, we analyzed the I/D genotype of 53 patients with that disorder. Twenty-two control subjects, who are volunteer Turkish patients without migraine, were included in the study. The frequency of the angiotensin-converting enzyme D/D genotype was statistically significant more frequent in patients with migraine with aura (81.1%) than in controls (59.1%) (P < .05). No differences were found regarding the I/I genotype and the I/D genotype between the 2 groups (P > .05). The results of our study revealed that the angiotensin-converting enzyme D/D genotype was more frequent in patients with migraine with aura than in controls. This might suggest that the angiotensin-converting enzyme D/D genotype may be a genetic risk factor for migraine with aura in Turkish patients.