Conflict of interest: The authors declare no conflict of interest.
Prion Protein Gene M129V Polymorphism and Variability in Age at Migraine Onset
Article first published online: 13 FEB 2013
© 2013 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 53, Issue 3, pages 540–545, March 2013
How to Cite
Palmirotta, R., Ludovici, G., Egeo, G., Ialongo, C., Aurilia, C., Fofi, L., De Marchis, M. L., Della-Morte, D., Barbanti, P. and Guadagni, F. (2013), Prion Protein Gene M129V Polymorphism and Variability in Age at Migraine Onset. Headache: The Journal of Head and Face Pain, 53: 540–545. doi: 10.1111/head.12043
- Issue published online: 13 MAR 2013
- Article first published online: 13 FEB 2013
- Manuscript Accepted: 7 NOV 2012
- Fondazione San Raffaele. Grant Number: MERIT RBNE08NKH7
- genetic polymorphism;
- prion protein;
- oxidative stress
Prion protein, a sialoglycoprotein with neuroprotective properties on oxidative stress damage, has been related with the mechanisms leading to migraine. In the present case-control study, we investigated the correlation between the common methionine/valine polymorphism at codon 129 within the prion protein gene (PRNP) and migraine. Genotyping of PRNP V129M variant was performed in 384 migraine patients and 185 age-, sex-, and race-ethnicity-matched healthy controls. The frequencies of the PRNP V129M genotype did not differ significantly between migraineurs and controls. The frequencies of 129VV genotype were significantly higher in patients with earlier age at migraine onset. No correlation was found between PRNP 129 genotype and demographics, and other clinical migraine features. Our data suggest that the PRNP 129VV polymorphism is not a direct migraine risk factor but is significantly associated with an earlier onset of the disease.