Get access

Prion Protein Gene M129V Polymorphism and Variability in Age at Migraine Onset

Authors

  • Raffaele Palmirotta MD, PhD,

    Corresponding author
    • Laboratory of Molecular Diagnostics, Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • Giorgia Ludovici PhD,

    1. Laboratory of Molecular Diagnostics, Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • Gabriella Egeo MD, PhD,

    1. Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • Cristiano Ialongo MD, PhD,

    1. Department of Internal Medicine, Faculty of Medicine and Surgery, University of Rome “Tor Vergata,”, Rome, Italy
    Search for more papers by this author
  • Cinzia Aurilia MD,

    1. Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • Luisa Fofi MD,

    1. Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • Maria Laura De Marchis PhD,

    1. Laboratory of Molecular Diagnostics, Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • David Della-Morte MD,

    1. Laboratory of Molecular Diagnostics, Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy
    2. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA
    Search for more papers by this author
  • Piero Barbanti MD, PhD,

    1. Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author
  • Fiorella Guadagni MD, PhD

    1. Laboratory of Molecular Diagnostics, Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy
    Search for more papers by this author

  • Conflict of interest: The authors declare no conflict of interest.

Address all correspondence to R. Palmirotta, Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, via della Pisana 235, 00163 Rome, Italy.

Abstract

Prion protein, a sialoglycoprotein with neuroprotective properties on oxidative stress damage, has been related with the mechanisms leading to migraine. In the present case-control study, we investigated the correlation between the common methionine/valine polymorphism at codon 129 within the prion protein gene (PRNP) and migraine. Genotyping of PRNP V129M variant was performed in 384 migraine patients and 185 age-, sex-, and race-ethnicity-matched healthy controls. The frequencies of the PRNP V129M genotype did not differ significantly between migraineurs and controls. The frequencies of 129VV genotype were significantly higher in patients with earlier age at migraine onset. No correlation was found between PRNP 129 genotype and demographics, and other clinical migraine features. Our data suggest that the PRNP 129VV polymorphism is not a direct migraine risk factor but is significantly associated with an earlier onset of the disease.

Get access to the full text of this article

Ancillary