Conflict of Interest: Dr. Gonzalez, Dr. Johnson, and Dr. Poulos received funding from GSK to conduct the present study. Dr. Runken was an employee of GSK at the time the study was conducted.
Evaluating Migraineurs' Preferences for Migraine Treatment Outcomes Using a Choice Experiment
Version of Record online: 28 JUN 2013
© 2013 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 53, Issue 10, pages 1635–1650, November/December 2013
How to Cite
Gonzalez, J. M., Johnson, F. R., Runken, M. C. and Poulos, C. M. (2013), Evaluating Migraineurs' Preferences for Migraine Treatment Outcomes Using a Choice Experiment. Headache: The Journal of Head and Face Pain, 53: 1635–1650. doi: 10.1111/head.12142
Financial Support: This study was funded by GlaxoSmithKline Plc.
- Issue online: 22 NOV 2013
- Version of Record online: 28 JUN 2013
- Manuscript Accepted: 24 APR 2013
- GlaxoSmithKline Plc
- patient preferences;
- conjoint analysis;
- ictal burden;
- interictal burden;
The impact of migraines on patients is commonly divided between the level of impairment associated with headache symptoms (headache phase) and the quality-of-life effects immediately following the headache (post-headache phase). Evaluations of migraineurs' productivity losses and health-related quality of life have provided an understanding of the burden associated with the headache and post-headache symptoms, but do not quantify the relative importance of each phase from a patient perspective. In this study, we evaluated migraineurs' willingness to accept trade-offs among symptom severity in the headache and post-headache phases, symptom duration in the headache and post-headache phases, and symptom-free time within a general-preference theoretic framework.
We administered a choice-format, conjoint-analysis survey, also called a discrete-choice experiment, to a sample of migraineurs from a nationally representative online consumer panel. After inclusion and exclusion criteria were applied, 510 eligible subjects completed the survey. The survey elicited choices between pairs of migraine profiles describing symptom durations and symptom-free time for the headache and post-headache phase.
Migraineurs in our study were strongly affected by the pain associated with the headache phase. However, experiencing difficulty with daily social and family activities in the post-headache phase also had a statistically significant impact on migraineurs' perceived level of well-being. Migraineurs reported that hypothetical treatments that limited the duration of headache symptoms without allowing them to resume their daily activities for 16 hours after a headache, on average, were less than half as good as treatments that limited both headache and post-headache symptoms.
Our results suggest that treatments that relieve and shorten symptoms during the post-headache phase can offer significant benefits to migraineurs.