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Migraine Genetics – A Review: Part I


  • This review article is based upon a chapter to be published in Dodick, D. and Silberstein, S. (ed.) Migraine, Second Edition. The book is to be published by Oxford University Press. Publication of this review article is with support from Oxford University Press.
  • Conflict of Interest: None.

Address all correspondence to S. Silberstein, Thomas Jefferson University – Neurology, Suite 8130, 111 South 11th Street, Gibbon Building, Philadelphia, PA 19107, USA.


Significant progress in molecular genetics has advanced our understanding of the genetic basis of migraine. The fundamentals of molecular genetics, and the recent advances in the field, are important for clinicians to understand, as they provide a foundation for critical appraisal of the literature, unprecedented insights into the pathogenesis of the disorder, and reveal promising treatment targets for future drug development. This paper provides a primer of molecular genetics and will be followed by a companion paper on the genetic advances in migraine, the methodology of genome wide association studies, and the potential clinical implications.