Conflict of Interest: The authors declare that there is no conflict of interest.
Genetic Analysis of GRIA2 and GRIA4 Genes in Migraine
Article first published online: 29 OCT 2013
© 2013 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 2, pages 303–312, February 2014
How to Cite
Gasparini, C. F., Sutherland, H. G., Haupt, L. M. and Griffiths, L. R. (2014), Genetic Analysis of GRIA2 and GRIA4 Genes in Migraine. Headache: The Journal of Head and Face Pain, 54: 303–312. doi: 10.1111/head.12234
- Issue published online: 10 FEB 2014
- Article first published online: 29 OCT 2013
- Manuscript Accepted: 5 SEP 2013
- a Griffith University Health Group Postgraduate scholarship
- Australian International Science Linkages
- Griffith University
- migraine with aura;
- migraine without aura;
- AMPA receptor;
Migraine is a brain disorder affecting ∼12% of the Caucasian population. Genes involved in neurological, vascular, and hormonal pathways have all been implicated in predisposing individuals to developing migraine. The migraineur presents with disabling head pain and varying symptoms of nausea, emesis, photophobia, phonophobia, and occasionally visual sensory disturbances. Biochemical and genetic studies have demonstrated dysfunction of neurotransmitters: serotonin, dopamine, and glutamate in migraine susceptibility. Glutamate mediates the transmission of excitatory signals in the mammalian central nervous system that affect normal brain function including cognition, memory and learning. The aim of this study was to investigate polymorphisms in the GRIA2 and GRIA4 genes, which encode subunits of the ionotropic AMPA receptor for association in an Australian Caucasian population.
Genotypes for each polymorphism were determined using high resolution melt analysis and the RFLP method.
Statistical analysis showed no association between migraine and the GRIA2 and GRIA4 polymorphisms investigated.
Although the results of this study showed no significant association between the tested GRIA gene variants and migraine in our Australian Caucasian population further investigation of other components of the glutamatergic system may help to elucidate if there is a relationship between glutamatergic dysfunction and migraine.