Conflict of Interest: The authors declare that there is no conflict of interest.
The Multitarget Drug Approach in Migraine Treatment: The New Challenge to Conquer
Article first published online: 29 OCT 2013
© 2013 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 1, pages 197–199, January 2014
How to Cite
González-Hernández, A. and Condés-Lara, M. (2014), The Multitarget Drug Approach in Migraine Treatment: The New Challenge to Conquer. Headache: The Journal of Head and Face Pain, 54: 197–199. doi: 10.1111/head.12237
- Issue published online: 8 JAN 2014
- Article first published online: 29 OCT 2013
- Manuscript Accepted: 8 AUG 2013
- National Autonomous University of Mexico (DGAPA-UNAM)
- network pharmacology;
- functional selectivity;
Migraine is a complex neurovascular disorder where a complex and interrelated neuronal spinal, supraspinal and central mechanisms are involved. Although we have greatly advanced in the knowledge of the main pathways involved in this disorder, the current drugs used are not effective in all patients, suggesting that the key mechanism related to headache relief remains elusive. In this context, the multi-target drug approach or network pharmacology emerges as a new step in the development of innovative migraine pharmacotherapy. The design, discovery, and development of new drugs that reach several (instead of unique) specific targets (functional selectivity) involved in the migraine pathophysiology is essential to progress in the migraine treatment and open a new field of study about the main pathways and targets that could synergistically improve the migraine management.