Conflict of Interest: None.
Obesity and Headache: Part II – Potential Mechanism and Treatment Considerations
Article first published online: 11 FEB 2014
© 2014 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 3, pages 459–471, March 2014
How to Cite
Chai, N. C., Bond, D. S., Moghekar, A., Scher, A. I. and Peterlin, B. L. (2014), Obesity and Headache: Part II – Potential Mechanism and Treatment Considerations. Headache: The Journal of Head and Face Pain, 54: 459–471. doi: 10.1111/head.12297
- Issue published online: 4 MAR 2014
- Article first published online: 11 FEB 2014
- Manuscript Accepted: 25 OCT 2013
- body mass index
Obesity and headache are both associated with a substantial personal and societal impact, and epidemiologic studies have consistently identified a positive association between obesity and headache in general, as well as obesity and migraine specifically (see part I). In the current manuscript, we will discuss the potential mechanisms for the migraine–obesity association, with a focus on the central and peripheral pathophysiological pathways which overlap between migraine and those modulating the drive to feed. We then discuss surgical, behavioral, and pharmacological treatment considerations for overweight and obese migraineurs as well as for those with idiopathic intracranial hypertension. We close by briefly discussing where future research may be headed in light of this data.