Conflict of Interest: None.
Migraine Headaches and Mood/Anxiety Disorders in the ELSA Brazil
Version of Record online: 4 JUN 2014
© 2014 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 8, pages 1310–1319, September 2014
How to Cite
Goulart, A. C., Santos, I. S., Brunoni, A. R., Nunes, M. A., Passos, V. M., Griep, R. H., Lotufo, P. A. and Benseñor, I. M. (2014), Migraine Headaches and Mood/Anxiety Disorders in the ELSA Brazil. Headache: The Journal of Head and Face Pain, 54: 1310–1319. doi: 10.1111/head.12397
Financial Support: The ELSA-Brasil baseline study was supported by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science and Technology (Financiadora de Estudos e Projetos and CNPq National Research Council) (grants 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00RJ).
- Issue online: 8 SEP 2014
- Version of Record online: 4 JUN 2014
- Manuscript Accepted: 10 APR 2014
- Brazilian Ministry of Health (Science and Technology Department)
- Brazilian Ministry of Science and Technology (Financiadora de Estudos e Projetos and CNPq National Research Council). Grant Numbers: 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00RJ
- mood disorder;
To describe the relationship between mood/anxiety disorders and migraine headaches emphasizing the frequency of episodes based in a cross-sectional analysis in the Brazilian Longitudinal Study of Adult Health.
It has been suggested that frequency of migraine headaches can be directly associated with the presence of psychiatric disorders.
Migraine headaches (International Headache Society criteria) was classified as <1×/month, 1×/month-1×/week, 2-6×/week, and daily. Psychiatric disorders using the Clinical Interview Schedule – Revised were classified in 6 categories: common mental (CMD), major depressive (MDD), generalized anxiety (GAD), panic, obsessive-compulsive (OCD), and mixed anxiety and depressive (MADD) disorders. We performed multivariate logistic models adjusted for age, race, education, marital status, income, and use of selective serotonin reuptake inhibitors.
In our sample, 1261 presented definite migraine and 10,531 without migraine headaches (reference). Our main result was an increase in the strength of association between migraine and MDD as frequency of migraine increased for all sample: odds ratio of 2.14 (95% confidence interval [CI] 1.33-3.43) for <1 episode of migraine/month to 6.94 (95% CI 4.20-11.49) for daily headaches for all sample. Significant associations with migraine were also found for GAD, OCD, MADD, and CMD for total sample: MDD, GAD, OCD, MADD, and CMD for women, and MADD and CMD for men. Among men with daily migraine complaint, we found a significant association between migraine and OCD after correction for multiple comparisons (odds ratio 29.86 [95% CI 4.66-191.43]). Analyzing probable and definite migraine cases together, we replicated the findings in a lower magnitude.
The increase in migraine frequency was associated with progressively higher frequencies of having mood/anxiety disorders in all samples suggesting for some psychiatric disorders a likely dose-response effect especially for women.