Conflict of Interest: Dr. Martin has the following disclosures:
Headache Currents—Clinical Review
Joint Hypermobility and Headache: The Glue That Binds the Two Together – Part 2
Article first published online: 23 JUN 2014
© 2014 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 8, pages 1403–1411, September 2014
How to Cite
Martin, V. T. and Neilson, D. (2014), Joint Hypermobility and Headache: The Glue That Binds the Two Together – Part 2. Headache: The Journal of Head and Face Pain, 54: 1403–1411. doi: 10.1111/head.12417
1. Allergan: Consultant, speaker
2. GSK: Research grants
3. Zogenix: Consultant, speaker
4. Nautilus: Consultant
5. Duramed: Speaker
Dr. Neilson declares no conflict of interest.
- Issue published online: 8 SEP 2014
- Article first published online: 23 JUN 2014
- Manuscript Accepted: 22 MAY 2014
- joint hypermobility syndrome;
- connective tissue disorder;
- Marfan's syndrome;
- Ehlers–Danlos syndrome
Past studies have reported that connective tissue disorders (CTDs) are more common in patients with specific types of headache disorders.
The objectives of this study are (1) to review and critique the clinical studies reporting an association between joint hypermobility, CTDs and headache and (2) to postulate mechanisms though which CTDs might predispose to headache disorders.
PubMed was searched for relevant articles with search terms that included joint hypermobility, Ehlers–Danlos syndrome, Marfan syndrome, and specific headache disorders. A narrative review was performed of these articles as well as those identified from the bibliography of these articles.
Case reports and case control studies confirm an association between CTDs and migraine, coat-hanger headaches, carotid arterial dissections, intracranial hypotension, Arnold Chiari malformations-type 1, cervical spine disorders, and temporomandibular joint disorders.
Observational cross-sectional studies suggest that the prevalence of CTDs is increased in patients with specific types of headache disorders. It is unknown if the CTDs directly cause these headaches disorders or are associated with them through other mechanisms.