Conflict of Interest:
Headache Currents—Clinical Review
Joint Hypermobility and Headache: Understanding the Glue That Binds the Two Together – Part 1
Article first published online: 16 JUL 2014
© 2014 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 8, pages 1393–1402, September 2014
How to Cite
Neilson, D. and Martin, V. T. (2014), Joint Hypermobility and Headache: Understanding the Glue That Binds the Two Together – Part 1. Headache: The Journal of Head and Face Pain, 54: 1393–1402. doi: 10.1111/head.12418
Dr. Neilson declares no conflict of interest.
Dr. Martin has the following disclosures:
1. Allergan: Consultant, speaker
2. GSK: Research grants
3. Zogenix: Consultant, speaker
4. Nautilus: Consultant
5. Duramed: Speaker
- Issue published online: 8 SEP 2014
- Article first published online: 16 JUL 2014
- Manuscript Accepted: 22 MAY 2014
- joint hypermobility syndrome;
- connective tissue disorder;
- Marfan syndrome;
- Ehlers–Danlos syndrome
Heritable connective tissue disorders (HCTD) present with a wide array of findings, including headache. Because of their unusual substrate, headaches in HCTD can derive from both common and uncommon circumstances.
Ehlers–Danlos hypermobile type can be recognized by multiple joint findings and its tendency to progress to a multisystem chronic pain syndrome. Ehlers–Danlos classic type also manifests joint laxity and similar pain complaints, but is differentiated by its skin laxity and fragility. Ehlers–Danlos vascular type presents the most severe risk due to blood vessel and hollow organ rupture. Marfan syndrome demonstrates skeletal abnormalities, lens dislocations, and aortic root dilation that can result in dissection.
In a headache patient, recognizing the presence of an HCTD improves the strategy for diagnosis and management. A brief review of findings related to joints, skin, and arteries may prompt further investigation into the HCTDs.