Conflict of Interest: None.
Views and Perspectives
Radioisotope Cisternography in Spontaneous CSF Leaks: Interpretations and Misinterpretations
Article first published online: 4 JUL 2014
© 2014 American Headache Society
Headache: The Journal of Head and Face Pain
Volume 54, Issue 8, pages 1358–1368, September 2014
How to Cite
Mokri, B. (2014), Radioisotope Cisternography in Spontaneous CSF Leaks: Interpretations and Misinterpretations. Headache: The Journal of Head and Face Pain, 54: 1358–1368. doi: 10.1111/head.12421
Sources of Financial Support: None.
- Issue published online: 8 SEP 2014
- Article first published online: 4 JUL 2014
- Manuscript Accepted: 18 MAY 2014
- radioisotope cisternography;
- cerebrospinal fluid leak;
- intracranial hypotension;
- urinary bladder uptake;
- meningeal diverticula
A broadening of the clinical and imaging features of the spontaneous cerebrospinal fluid (CSF) leaks is now well recognized, far beyond what was thought only two decades ago. This has resulted in increasing number of patients with atypical and unusual features who, not unexpectedly, are directed to headache specialists and tertiary referral centers. In many cases, obviously the fundamental question of presence or absence of CSF leak will need to be addressed prior to proceeding with further and often more involved, more invasive, and more costly diagnostic and therapeutic considerations. Radioisotope cisternography often proves to be very helpful in these situations by demonstrating reliable, although indirect, evidences of CSF leak while it is less helpful in directly identifying the exact site of the CSF leakage. In this overview article, the expectations from and the limitations of this diagnostic method are described along with some personal observations in the past 25 years.