Quality of life after adult living donor liver transplantation: A longitudinal prospective follow-up study
Article first published online: 1 FEB 2013
© 2013 The Japan Society of Hepatology
Volume 43, Issue 10, pages 1052–1063, October 2013
How to Cite
Togashi, J., Sugawara, Y., Akamatsu, N., Tamura, S., Yamashiki, N., Kaneko, J., Sakamoto, Y., Aoki, T., Hasegawa, K. and Kokudo, N. (2013), Quality of life after adult living donor liver transplantation: A longitudinal prospective follow-up study. Hepatology Research, 43: 1052–1063. doi: 10.1111/hepr.12060
- Issue published online: 3 OCT 2013
- Article first published online: 1 FEB 2013
- Accepted manuscript online: 3 JAN 2013 07:26AM EST
- Manuscript Accepted: 25 DEC 2012
- Manuscript Revised: 23 DEC 2012
- Manuscript Received: 19 NOV 2012
- health-related quality of life;
- liver transplantation;
- living donor liver transplantation;
- quality of life;
- Short Form-36
Patient survival after living donor liver transplantation (LDLT) has improved, but improvement of the health-related quality of life (HRQOL) of LDLT recipients is also an important issue. The aim of this study was to assess the HRQOL of LDLT recipients from the preoperative period to 18 months following transplantation by prospectively evaluating Short Form-36 Version 2 (SF-36v2) scores.
Complete longitudinal SF-36v2 scores were collected from 35 consecutive LDLT recipients prior to surgery and at 3, 6, 12 and 18 months after transplantation.
HRQOL scores were severely impaired in all dimensions preoperatively. Although the scores improved significantly up to 18 months after transplantation, they remained lower than those of healthy controls in the majority of domains. Impaired scores preoperatively were significantly associated with severity of liver disease represented by a higher Model for End-Stage Liver Disease (MELD) score and Child–Turcotte–Pugh class C, and scores in such patients improved significantly after LDLT in every dimension at 12 months, indicating that the greater the impairment at the pretransplant stage, the greater the improvement in both physical and mental conditions. Preoperative lower HRQOL scores and higher MELD scores were independently associated with significant physical and mental score gains during the first year after LDLT.
The findings of the present study may facilitate the development of measures aimed at improving recipient's post-transplant life and establishing realistic expectations for LDLT recipients.