Spleen magnetic resonance diffusion-weighted imaging for quantitative staging hepatic fibrosis in miniature pigs: An initial study
Article first published online: 20 FEB 2013
© 2013 The Japan Society of Hepatology
Volume 43, Issue 11, pages 1231–1240, November 2013
How to Cite
Chen, X.-l., Chen, T.-w., Zhang, X.-m., Li, Z.-l., Li, H., Zeng, N.-l., Tang, H.-j., Pu, Y., Chen, N., Yang, Q., Li, L., Xie, X.-y. and Hu, J. (2013), Spleen magnetic resonance diffusion-weighted imaging for quantitative staging hepatic fibrosis in miniature pigs: An initial study. Hepatology Research, 43: 1231–1240. doi: 10.1111/hepr.12076
- Issue published online: 28 OCT 2013
- Article first published online: 20 FEB 2013
- Accepted manuscript online: 25 JAN 2013 09:05AM EST
- Manuscript Accepted: 16 JAN 2013
- Manuscript Revised: 15 JAN 2013
- Manuscript Received: 25 NOV 2012
- National Natural Science Foundation of China. Grant Number: 81050033
- Key Projects in the Sichuan Province Science & Technology Pillar Program. Grant Number: 2011SZ0237
- Science Foundation for Distinguished Young Scholars of Sichuan Province, China. Grant Number: 2010JQ0039
- apparent diffusion coefficient;
- diffusion-weighted imaging;
- exponential apparent diffusion coefficient;
- liver fibrosis;
- signal intensity;
To determine whether spleen diffusion-weighted imaging (DWI) parameters might classify liver fibrosis stage.
Sixteen miniature pigs were prospectively used to model liver fibrosis, and underwent spleen DWI by using b = 300, 500 and 800 s/mm2 on 0, 5th, 9th, 16th and 21st weekend after the beginning of modeling. Signal intensity ratio of spleen to paraspinous muscles (S/M), spleen exponential apparent diffusion coefficient (eADC) and apparent diffusion coefficient (ADC) for each b-value were statistically analyzed.
With increasing stages of fibrosis, S/M for all b-values showed a downward trend; and spleen eADC and ADC for b = 300 s/mm2 showed downward and upward trends, respectively (all P < 0.05). The area under the receiver–operator curve (AUC) of spleen DWI parameters was 0.777 or more by S/M for classifying each fibrosis stage, and 0.65 or more by eADC and 0.648 or more by ADC for classifying stage ≥3 or cirrhosis. Among the spleen DWI parameters, S/M for b = 300 s/mm2 was the best parameter in classifying stage 1 or more, 2 or more and 3 or more with AUC of 0.875, 0.851 and 0.843, respectively; and spleen eADC for b = 300 s/mm2 was best in classifying stage 4 with an AUC of 0.988.
Spleen DWI may be used to stage liver fibrosis.