Spleen magnetic resonance diffusion-weighted imaging for quantitative staging hepatic fibrosis in miniature pigs: An initial study

Authors

  • Xiao-li Chen,

    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Tian-wu Chen,

    Corresponding author
    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
    2. Department of Radiology, Wayne State University, Detroit, Michigan, USA
    • Correspondence: Prof Tian-wu Chen, Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Shunqing District, Nanchong 637000, Sichuan, China. Email: twchenscu@yahoo.com.cn

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  • Xiao-ming Zhang,

    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Zhen-lin Li,

    1. Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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  • Hang Li,

    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Nan-lin Zeng,

    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Hong-jie Tang,

    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Yu Pu,

    1. Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Nan Chen,

    1. Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China
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  • Qi Yang,

    1. Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China
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  • Li Li,

    1. Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Xian-yong Xie,

    1. Department of Pathology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China
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  • Jiani Hu

    1. Department of Radiology, Wayne State University, Detroit, Michigan, USA
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Abstract

Aim

To determine whether spleen diffusion-weighted imaging (DWI) parameters might classify liver fibrosis stage.

Methods

Sixteen miniature pigs were prospectively used to model liver fibrosis, and underwent spleen DWI by using b = 300, 500 and 800 s/mm2 on 0, 5th, 9th, 16th and 21st weekend after the beginning of modeling. Signal intensity ratio of spleen to paraspinous muscles (S/M), spleen exponential apparent diffusion coefficient (eADC) and apparent diffusion coefficient (ADC) for each b-value were statistically analyzed.

Results

With increasing stages of fibrosis, S/M for all b-values showed a downward trend; and spleen eADC and ADC for b = 300 s/mm2 showed downward and upward trends, respectively (all P < 0.05). The area under the receiver–operator curve (AUC) of spleen DWI parameters was 0.777 or more by S/M for classifying each fibrosis stage, and 0.65 or more by eADC and 0.648 or more by ADC for classifying stage ≥3 or cirrhosis. Among the spleen DWI parameters, S/M for b = 300 s/mm2 was the best parameter in classifying stage 1 or more, 2 or more and 3 or more with AUC of 0.875, 0.851 and 0.843, respectively; and spleen eADC for b = 300 s/mm2 was best in classifying stage 4 with an AUC of 0.988.

Conclusion

Spleen DWI may be used to stage liver fibrosis.

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