Conflict of interest statement: None of the authors has declared any conflict of interest pertaining to this manuscript.
Correlation of hepatitis B surface antigen level with response to telbivudine in naive patients with chronic hepatitis B
Article first published online: 10 MAY 2013
© 2013 The Japan Society of Hepatology
Volume 44, Issue 2, pages 187–193, February 2014
How to Cite
Li, X., Wang, Y., Han, D., Zhang, W., Zhang, Z., Ye, X., Tian, L., Dong, Y., Zhu, Q. and Chen, Y. (2014), Correlation of hepatitis B surface antigen level with response to telbivudine in naive patients with chronic hepatitis B. Hepatology Research, 44: 187–193. doi: 10.1111/hepr.12105
- Issue published online: 5 FEB 2014
- Article first published online: 10 MAY 2013
- Accepted manuscript online: 4 MAR 2013 07:55AM EST
- Manuscript Accepted: 24 FEB 2013
- Manuscript Revised: 31 JAN 2013
- Manuscript Received: 10 OCT 2012
- National Natural Science Foundation of China. Grant Number: 81171565
- chronic hepatitis B;
- hepatitis B surface antigen;
- treatment response
Hepatitis B surface antigen (HBsAg) has become a marker to judge immunological response to hepatitis B therapy. Quantified serum HBsAg levels can predict the response to pegylated interferon and entecavir. In this study, we aimed to explore the correlation of serum HBsAg levels with response to telbivudine (LdT) treatment in patients with chronic hepatitis B (CHB).
Seventy-three treatment-naive CHB patients were recruited and received LdT monotherapy for 52 weeks and serial HBsAg levels were measured at five protocol time points. According to therapeutic efficacy at week 52, three subgroups of patients were identified, including complete responders (CR), partial responders (PR) and non-responders (NR).
After 52 weeks of treatment, CR, PR and NR represented 19 (26%), 33 (45%) and 21 (29%) patients in the sample of 73, respectively. The median values of baseline HBsAg (log10 IU/mL) were 4.05, 4.50 and 5.03 for CR, PR and NR, respectively. There was a distinct decline of HBsAg at week 52; median log10 HBsAg levels (IU/mL) were 3.61 (CR), 3.86 (PR) and 4.31 (NR). Positive correlation between HBsAg levels and HBV DNA loads was observed in the group of NR and early antiviral treatment of PR, but not in CR.
Initial HBsAg level was closely correlated with the efficacy of LdT. Patients with low HBsAg levels presented satisfactory responses. Therefore, initial level and correlation with HBV DNA of the serum HBsAg levels could predict responsiveness in CHB patients receiving LdT.