These authors contributed equally to this study.
Association between dental infections and the clinical course of chronic liver disease
Article first published online: 29 APR 2013
© 2013 The Japan Society of Hepatology
Volume 44, Issue 3, pages 349–353, March 2014
How to Cite
Åberg, F., Helenius-Hietala, J., Meurman, J. and Isoniemi, H. (2014), Association between dental infections and the clinical course of chronic liver disease. Hepatology Research, 44: 349–353. doi: 10.1111/hepr.12126
Conflict of interest: None of the authors have any conflict of interest to disclose.
Funding: No grants were received for this study.
- Issue published online: 3 MAR 2014
- Article first published online: 29 APR 2013
- Accepted manuscript online: 5 APR 2013 05:18AM EST
- Manuscript Accepted: 27 MAR 2013
- Manuscript Revised: 26 MAR 2013
- Manuscript Received: 30 NOV 2012
- liver fibrosis;
- oral health;
Dental infections are implicated in several systemic diseases due to bacteremia and pro-inflammatory effects, but their possible role in liver disease is unclear.
We retrospectively analyzed the clinical course of liver disease in relation to dental health among 116 patients with liver cirrhosis who underwent dental examination before liver transplantation.
The need for multiple tooth extractions, a surrogate marker of dental infections, was associated with reduced time from diagnosis of liver disease to the need for liver transplantation (P = 0.02). The association was independent of age, sex, liver disease etiology and Model for End-Stage Liver Disease (MELD) score (P = 0.04). Among 38 patients with accurate laboratory follow-up data, the number of tooth extractions correlated with the change in MELD score during the year preceding dental examination (r = 0.43, P = 0.03). Spontaneous bacterial peritonitis caused by Streptococcus viridans occurred only among patients with multiple dental infections.
Dental infections may influence the clinical course of liver disease, but prospective studies are needed.