These authors contributed equally to this study.
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Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma
Article first published online: 28 SEP 2012
DOI: 10.1111/his.12001
© 2012 Blackwell Publishing Limited.
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How to Cite
Pichler, M., Hutterer, G. C., Chromecki, T. F., Jesche, J., Kampel-Kettner, K., Groselj-Strele, A., Hoefler, G., Pummer, K. and Zigeuner, R. (2013), Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma. Histopathology, 62: 237–246. doi: 10.1111/his.12001
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These authors contributed equally to this study.
Publication History
- Issue published online: 13 DEC 2012
- Article first published online: 28 SEP 2012
- Accepted manuscript online: 27 JUL 2012 04:20AM EST
- Date of submission 28 February 2012 Accepted for publication 13 July 2012
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Keywords:
- predictive ability;
- prognosis;
- renal cell carcinoma;
- TNM classification
Aims: A novel version of the tumour–node–metastasis (TNM) classification system for renal cell carcinoma (RCC) was introduced in 2010, although the prognostic significance with regard to different histological subtypes has not been explored. Therefore, the aim of our study was to compare the predictive ability of the 2002 and 2010 versions of the TNM classification system for clear cell and papillary RCC.
Methods and results: Data from 2263 consecutive clear cell and 309 papillary RCC patients, operated at a single tertiary academic centre, were evaluated. According to TNM 2010, statistically significant differences for cancer-specific survival (CSS) were observed for pT1a versus pT1b (P < 0.001) and pT3a versus pT3b (P < 0.004) in clear cell RCC; and pT1b versus pT2a (P = 0.002) and pT3b versus pT3c (P = 0.046) in papillary RCC. The c-index for CSS in clear cell RCC was 0.74 and 0.73, and in papillary RCC 0.79 and 0.78, for the 2002 and 2010 versions of the TNM classification system, respectively.
Conclusions: According to our data, the predictive ability of the 2010 version of the TNM classification system regarding CSS is not superior to the 2002 version, either in clear cell or in papillary RCC.