A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord–stromal tumours
Article first published online: 13 DEC 2012
© 2012 Blackwell Publishing Limited.
Volume 62, Issue 1, pages 71–88, January 2013
How to Cite
2013) Histopathology 62, 71–88 A practical approach to immunohistochemical diagnosis of ovarian germ cell tumours and sex cord–stromal tumours& (
- Issue published online: 13 DEC 2012
- Article first published online: 13 DEC 2012
- Accepted manuscript online: 25 OCT 2012 07:11AM EST
- Manuscript Accepted: 20 OCT 2012
- Manuscript Received: 18 SEP 2012
- germ cell tumour;
- sex cord–stromal tumour
Immunohistochemistry can be useful in the diagnosis of ovarian germ cell tumours and sex cord–stromal tumours. A wide variety of markers are available, including many that are novel. The aim of this review is to provide a practical approach to the selection and interpretation of these markers, emphasizing an understanding of their sensitivity and specificity in the particular differential diagnosis in question. The main markers discussed include those for malignant germ cell differentiation (SALL4 and placental alkaline phosphatase), dysgerminoma (OCT4, CD117, and D2-40), yolk sac tumour (α-fetoprotein and glypican-3), embryonal carcinoma (OCT4, CD30, and SOX2), sex cord–stromal differentiation (calretinin, inhibin, SF-1, FOXL2) and steroid cell tumours (melan-A). In addition, the limited role of immunohistochemistry in determining the primary site of origin of an ovarian carcinoid tumour is discussed.