The presence of clusters of plasmacytoid dendritic cells is a helpful feature for differentiating lupus panniculitis from subcutaneous panniculitis-like T-cell lymphoma
Version of Record online: 18 APR 2013
© 2013 Blackwell Publishing Ltd
Volume 62, Issue 7, pages 1057–1066, June 2013
How to Cite
2013) Histopathology62, 1057–1066 The presence of clusters of plasmacytoid dendritic cells is a helpful feature for differentiating lupus panniculitis from subcutaneous panniculitis-like T-cell lymphoma, , , , & (
- Issue online: 16 MAY 2013
- Version of Record online: 18 APR 2013
- Accepted manuscript online: 30 JAN 2013 09:18PM EST
- Manuscript Accepted: 28 JAN 2013
- Manuscript Received: 17 DEC 2012
- lupus panniculitis;
- plasmacytoid dendritic cells;
- subcutaneous panniculitis-like T-cell lymphoma
Both lupus panniculitis (LP) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL) are characterized by subcutaneous lobular lymphocytic infiltrates, and they are sometimes difficult to differentiate. Recently, plasmacytoid dendritic cells (PDCs) were found to be present in various types of cutaneous lupus erythematosus lesions, including LP, and are supposed to play important pathogenetic roles. The aim of this study was to investigate whether PDCs are differentially present in these two diseases and can be utilized to differentiate them. Conventional histopathological features were also compared.
Methods and results
Initial biopsies from 21 LP and 11 SPTCL patients were analysed. Our results showed that the presence of lymphoid follicles, dermal mucin deposition and lack of moderate to marked nuclear atypia or adipocyte rimming were more suggestive of LP. Several distinct patterns of fat necrosis, i.e. hyaline/lipomembranous and fibrinoid/coagulative in LP and SPTCL, respectively, were also diagnostically useful. Also, clusters of PDCs were characteristically seen in LP lesions (17/21, 81%) but not in SPTCL lesions (2/11, 18.2%). In LP lesions, but not in SPTCL lesions, the presence of epidermal interface change correlated perfectly with the presence of PDCs in the papillary dermis.
We conclude that the presence of clusters of PDCs and certain histological features are helpful for the differential diagnosis.