PBK/TOPK expression in non-small-cell lung cancer: its correlation and prognostic significance with Ki67 and p53 expression

Authors

  • Bin Lei,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Shuguang Liu,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Wenjuan Qi,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Yunfei Zhao,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Yumei Li,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Ni Lin,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Xiaoyan Xu,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Chen Zhi,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Juanjuan Mei,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Zhimin Yan,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Liyan Wan,

    1. Department of Pathology, Nanfang Hospital, Guangzhou, China
    2. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Search for more papers by this author
  • Hong Shen

    Corresponding author
    1. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    • Department of Pathology, Nanfang Hospital, Guangzhou, China
    Search for more papers by this author

Address for correspondence: H Shen, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou City 515000, China. e-mail: shenhong2010168@163.com

Abstract

Aims

The aim of this study was to evaluate the prevalence of PBK/TOPK (PDZ-binding kinase/T-LAK cell-originated protein kinase) expression, and explore the prognostic significance of PBK/TOPK expression alone and in combination with Ki67 and p53 expression in non-small-cell lung cancer (NSCLC).

Methods and results

We detected PBK/TOPK expression in 30 samples of normal lung tissue, 32 lymph node metastases and 279 primary non-small-cell lung cancers by immunohistochemistry, and analysed the correlation of PBK/TOPK expression with Ki67 and p53 expression in primary tumour tissues. The results showed that PBK/TOPK expression was higher in lymph node metastases (75%) than in primary tumours (44.8%) and normal lung tissues (0%). PBK/TOPK expression was associated with histological type, lymph node metastasis, and TNM stage, and was positively correlated with Ki67 and p53 expression in NSCLC. Univariate and multivariate survival analyses showed that PBK/TOPK expression was significantly associated with an unfavourable prognosis in NSCLC. The prognosis of patients with tumours positive for both PBK/TOPK expression and Ki67 or p53 expression was also significantly unfavourable.

Conclusions

PBK/TOPK expression is positively correlated with Ki67 and p53 expression, and can be used as an independent prognostic factor in NSCLC.

Ancillary