Antibodies are forever: a study using 12–26-year-old expired antibodies

Authors


Abstract

Aims

The aim of this study was to investigate whether the shelf-life of diagnostic antibodies is longer than the expiry date on the label.

Methods and results

Four independent laboratories tested a small number of diagnostic antibodies kept at +4°C for 12–26 years, and found them to work perfectly on routine histology sections.

Conclusions

Diagnostic antibodies may have a workable half-life in excess of 10 years, and the emphasis on performance should shift to the preservation of antigenic targets in the tissue.

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