Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily
Article first published online: 3 JUN 2013
© 2013 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.
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Volume 15, Issue 1, pages 50–56, January 2014
How to Cite
Zorrilla, C., Wright, R., Osiyemi, O., Yasin, S., Baugh, B., Brown, K., Coate, B., Verboven, P., Mrus, J., Falcon, R. and Kakuda, T. (2014), Total and unbound darunavir pharmacokinetics in pregnant women infected with HIV-1: results of a study of darunavir/ritonavir 600/100 mg administered twice daily. HIV Medicine, 15: 50–56. doi: 10.1111/hiv.12047
- Issue published online: 3 DEC 2013
- Article first published online: 3 JUN 2013
- Manuscript Accepted: 12 APR 2013
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Fig. S1 Individual minimum plasma concentrations of total darunavir (A), unbound darunavir (B) and total ritonavir (C) after administration of darunavir/ritonavir 600/100 mg twice daily (bid), during the second and third trimesters and postpartum.
Fig. S2 Mean (standard error) plasma concentration–time curves for albumin (A) and α1-acid glycoprotein (AAG) (B) assessed at various time-points throughout the study.
Fig. S3 Antiviral activity expressed as percentage response rate (A) (only patients who completed the study in its entirety are included) and status of the immune system expressed as median percentage CD4 count (B) assessed at various time-points throughout the study.
Table S1 Baseline demographics, disease characteristics and study discontinuations.
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