Co-Chair, Canadian Institutes for Health Research−Canadian HIV Trials Network, Co-Infection and Concurrent Diseases Core Working Group.
HIV/hepatitis C virus coinfection management: changing guidelines and changing paradigms
Article first published online: 6 MAY 2014
© 2014 British HIV Association
Volume 15, Issue 10, pages 621–624, November 2014
How to Cite
Cooper, C. and Klein, M. (2014), HIV/hepatitis C virus coinfection management: changing guidelines and changing paradigms. HIV Medicine, 15: 621–624. doi: 10.1111/hiv.12161
- Issue published online: 21 OCT 2014
- Article first published online: 6 MAY 2014
- Manuscript Accepted: 25 MAR 2014
- Canadian Institutes for Health Research−Canadian HIV Trials Network
- hepatitis C virus;
The aim of the study was to consider the impact of new direct-acting antiviral (DAA) regimens on hepatitis C virus (HCV) treatment in HIV/HCV coinfection.
Current coinfection guidelines were reviewed and the impact of recent DAA publications evaluating HIV-coinfected individuals was considered.
Current coinfection guidelines recommend HIV antiretroviral therapy initiation prior to HCV antiviral therapy. New all-oral, combination antiviral therapy composed of one or more DAAs with or without ribavirin will change this paradigm. As these regimens are better tolerated, it will be possible to offer nearly all HCV-infected patients antiviral therapy, including those with HIV infection. All-oral regimens may impact the incidence of HCV infection by providing a treatment option that can be safely and broadly utilized in high-risk populations with the benefits of curing individual patients and addressing broader public health concerns related to HCV.
HCV infection treatment should no longer be a secondary consideration restricted to the minority of HIV/HCV-coinfected patients.