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Skin viscoelasticity during hormone replacement therapy for climacteric ageing

Authors

  • G. E. Piérard,

    Corresponding author
    1. Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, B23, University of Liège, Liège, Belgium
    • Correspondence: Gérald E. Piérard, Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, B23, University of Liège, B-4000 Liège, Belgium. Tel.: +32 4 3662408; fax: +32 4 3662976; e-mail: gerald.pierard@ulg.ac.be

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  • T. Hermanns-Lê,

    1. Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, B23, University of Liège, Liège, Belgium
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  • P. Paquet,

    1. Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, B23, University of Liège, Liège, Belgium
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  • C. Piérard-Franchimont

    1. Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, B23, University of Liège, Liège, Belgium
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Synopsis

Background

Climacteric ageing refers to the period of women's life centred by the perimenopause. This step of life is responsible for initiating skin atrophic withering and slackness responsible for changes in the viscoelasticity of the dermal connective tissue. Some women benefit from hormone replacement therapy (HRT) for controlling some unpleasant internal climacteric changes (osteoporosis, vasomotor instability, …).

Objective

To investigate some corrective effects of HRT on the functional damages in the dermal tensile strength.

Patients and Methods

This study was performed on 200 healthy Caucasian women. In vivo skin viscoelasticity was assessed using the suction method.

Results

Skin distensibility and hysteresis appeared increased at menopause with or without HRT. By contrast, the biological elasticity significantly decreased out of HRT.

Conclusion

Some drugs and cosmetics might attempt at improving such viscoelastic attributes of the skin at menopause.

Résumé

Contexte

Le vieillissement lié au climatère correspond à une phase de la vie féminine centrée sur la périménopause. Cette période de la vie correspond à l'installation d'une atrophie, d'un déclin tissulaire et d'une laxité cutanée responsable d'altérations de la viscoélasticité du tissu conjonctif dermique. Certaines femmes bénéficient d'un traitement hormonal substitutif (THS) pour contrôler certaines altérations déplaisantes internes (ostéoporose, instabilité vasomotrice, …).

Objectif

Evaluer l'effet du THS susceptible de corriger certains dommages fonctionnels de la biomécanique du derme.

Patients et Methode

La méthode par succion a été utilisée chez 200 femmes caucasiennes saines.

Resultats

La distensibilité cutanée et l'hystérèse sont apparues accrues lors de la ménopause avec ou sans THS. En revanche, l'élasticité biologique est apparue diminuée chez les femmes hors THS.

Conclusion

Certains médicaments et cosmétiques pourraient tenter d'améliorer ces qualités viscoélastiques de la peau à la ménopause.

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