The present work aims at synthesis and study the bioactivity of porous alumina scaffolds coated with calcium pyrophosphate. Characterization of the formed calcium pyrophosphate and the coated scaffolds was assessed by X-ray diffraction analysis and scanning electron microscope examinations. The in vivo studies revealed the ability of the porous scaffolds to regenerate bone tissue in femur defects of albino rats. Histological analysis showed that the defect is almost entirely filled with new bone. The formed bone is characterized as a mature bone. The produced bone grafts are intended to be used as bone substitute or bone filler.