Loading and Delivery of Anticancer Drugs using Montmorillonite

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Abstract

This study aimed to investigate in vitro the montmorillonite (MMT) as carrier for gemcitabine hydrochloride (dFdU.HCl) and oxaliplatin (DACH-Pt). The maximum adsorption capacities of MMT and their respective mechanisms were determined through a soaking procedure (387.5 mg dFdU.HCl/g MMT were adsorbed in 32 h, 83 mg DACH-Pt/g MMT in 48 h). Release kinetics studies were carried out soaking the samples of loaded MMT in simulated body fluids (SBF). Finally, in an attempt to explain the mechanism of drug delivery, the chemical interactions were studied theoretically, according to the adsorption and release profiles.

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